Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients
To investigate whether patients with obstructive sleep apnea (OSA) are at risk of sedation-related complications during diagnostic esophagogastroduodenoscopy (EGD). A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 201...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2013-08, Vol.19 (29), p.4745-4751 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Cha, Jae Myung Jeun, Jung Won Pack, Kwan Mi Lee, Joung Il Joo, Kwang Ro Shin, Hyun Phil Shin, Won-Chul |
| description | To investigate whether patients with obstructive sleep apnea (OSA) are at risk of sedation-related complications during diagnostic esophagogastroduodenoscopy (EGD).
A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 2010 and April 2011. The occurrence of cardiopulmonary complications related to sedation during diagnostic EGD was compared between OSA and control groups.
During the study period, 31 patients with OSA and 65 controls were enrolled. Compared with the control group, a higher dosage of midazolam was administered (P = 0.000) and a higher proportion of deep sedation was performed (P = 0.024) in the OSA group. However, all adverse events, including sedation failure, paradoxical responses, snoring or apnea, hypoxia, hypotension, oxygen or flumazenil administration, and other adverse events were not different between the two groups (all P > 0.1). Patients with OSA were not predisposed to hypoxia with multivariate logistic regression analysis (P = 0.068).
In patients with OSA, this limited sized study did not disclose an increased risk of cardiopulmonary complications during diagnostic EGD under sedation. |
| doi_str_mv | 10.3748/wjg.v19.i29.4745 |
| format | Article |
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A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 2010 and April 2011. The occurrence of cardiopulmonary complications related to sedation during diagnostic EGD was compared between OSA and control groups.
During the study period, 31 patients with OSA and 65 controls were enrolled. Compared with the control group, a higher dosage of midazolam was administered (P = 0.000) and a higher proportion of deep sedation was performed (P = 0.024) in the OSA group. However, all adverse events, including sedation failure, paradoxical responses, snoring or apnea, hypoxia, hypotension, oxygen or flumazenil administration, and other adverse events were not different between the two groups (all P > 0.1). Patients with OSA were not predisposed to hypoxia with multivariate logistic regression analysis (P = 0.068).
In patients with OSA, this limited sized study did not disclose an increased risk of cardiopulmonary complications during diagnostic EGD under sedation.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v19.i29.4745</identifier><identifier>PMID: 23922472</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Adult ; Brief ; Case-Control Studies ; Chi-Square Distribution ; Deep Sedation - adverse effects ; Endoscopy, Digestive System - adverse effects ; Female ; Humans ; Hypnotics and Sedatives - administration & dosage ; Hypnotics and Sedatives - adverse effects ; Hypotension - etiology ; Hypoxia - etiology ; Logistic Models ; Male ; Midazolam - administration & dosage ; Midazolam - adverse effects ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Polysomnography ; Predictive Value of Tests ; Prospective Studies ; Respiratory Tract Diseases - etiology ; Risk Assessment ; Risk Factors ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - diagnosis</subject><ispartof>World journal of gastroenterology : WJG, 2013-08, Vol.19 (29), p.4745-4751</ispartof><rights>2013 Baishideng Publishing Group Co., Limited. All rights reserved. 2013</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-8d4d8e831963b2c193fa92fc7d88a11070967d88f040fcd3adaa48ee4b95297f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732847/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732847/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23922472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cha, Jae Myung</creatorcontrib><creatorcontrib>Jeun, Jung Won</creatorcontrib><creatorcontrib>Pack, Kwan Mi</creatorcontrib><creatorcontrib>Lee, Joung Il</creatorcontrib><creatorcontrib>Joo, Kwang Ro</creatorcontrib><creatorcontrib>Shin, Hyun Phil</creatorcontrib><creatorcontrib>Shin, Won-Chul</creatorcontrib><title>Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To investigate whether patients with obstructive sleep apnea (OSA) are at risk of sedation-related complications during diagnostic esophagogastroduodenoscopy (EGD).
A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 2010 and April 2011. The occurrence of cardiopulmonary complications related to sedation during diagnostic EGD was compared between OSA and control groups.
During the study period, 31 patients with OSA and 65 controls were enrolled. Compared with the control group, a higher dosage of midazolam was administered (P = 0.000) and a higher proportion of deep sedation was performed (P = 0.024) in the OSA group. However, all adverse events, including sedation failure, paradoxical responses, snoring or apnea, hypoxia, hypotension, oxygen or flumazenil administration, and other adverse events were not different between the two groups (all P > 0.1). Patients with OSA were not predisposed to hypoxia with multivariate logistic regression analysis (P = 0.068).
In patients with OSA, this limited sized study did not disclose an increased risk of cardiopulmonary complications during diagnostic EGD under sedation.</description><subject>Adult</subject><subject>Brief</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Deep Sedation - adverse effects</subject><subject>Endoscopy, Digestive System - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Hypotension - etiology</subject><subject>Hypoxia - etiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Midazolam - administration & dosage</subject><subject>Midazolam - adverse effects</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Polysomnography</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Respiratory Tract Diseases - etiology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEURYMotlb3riR_YMZ8tUk2ghSrQkEQ3Roy-ZimtpNhMq3035tSLbp6j3e558EB4BqjknImbr-WdbnFsgxEloyz8QkYEoJlQQRDp2CIEeKFpIQPwEVKS4QIpWNyDgaESkIYJ0Pw8RrSJ4weJmd1H2IDfeygDbpuYuqDgS7FdqHrWOvUd9FuonU5MbHdwdDAWOXrxvRh62BaOddC3TZOwzazXNOnS3Dm9Sq5q585Au-zh7fpUzF_eXye3s8LQ-WkL4RlVjhBsZzQihgsqdeSeMOtEBpjxJGc7HePGPLGUm21ZsI5VskxkdzTEbg7cNtNtXbW5N-dXqm2C2vd7VTUQf1PmrBQddwqymmWxTMAHQCmiyl1zh-7GKm9a5Vdq-xaZddq7zpXbv7-PBZ-5dJvnRGAFw</recordid><startdate>20130807</startdate><enddate>20130807</enddate><creator>Cha, Jae Myung</creator><creator>Jeun, Jung Won</creator><creator>Pack, Kwan Mi</creator><creator>Lee, Joung Il</creator><creator>Joo, Kwang Ro</creator><creator>Shin, Hyun Phil</creator><creator>Shin, Won-Chul</creator><general>Baishideng Publishing Group Co., Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20130807</creationdate><title>Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients</title><author>Cha, Jae Myung ; Jeun, Jung Won ; Pack, Kwan Mi ; Lee, Joung Il ; Joo, Kwang Ro ; Shin, Hyun Phil ; Shin, Won-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-8d4d8e831963b2c193fa92fc7d88a11070967d88f040fcd3adaa48ee4b95297f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Brief</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Deep Sedation - adverse effects</topic><topic>Endoscopy, Digestive System - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Hypnotics and Sedatives - adverse effects</topic><topic>Hypotension - etiology</topic><topic>Hypoxia - etiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Midazolam - administration & dosage</topic><topic>Midazolam - adverse effects</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Polysomnography</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Respiratory Tract Diseases - etiology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><toplevel>online_resources</toplevel><creatorcontrib>Cha, Jae Myung</creatorcontrib><creatorcontrib>Jeun, Jung Won</creatorcontrib><creatorcontrib>Pack, Kwan Mi</creatorcontrib><creatorcontrib>Lee, Joung Il</creatorcontrib><creatorcontrib>Joo, Kwang Ro</creatorcontrib><creatorcontrib>Shin, Hyun Phil</creatorcontrib><creatorcontrib>Shin, Won-Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cha, Jae Myung</au><au>Jeun, Jung Won</au><au>Pack, Kwan Mi</au><au>Lee, Joung Il</au><au>Joo, Kwang Ro</au><au>Shin, Hyun Phil</au><au>Shin, Won-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2013-08-07</date><risdate>2013</risdate><volume>19</volume><issue>29</issue><spage>4745</spage><epage>4751</epage><pages>4745-4751</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To investigate whether patients with obstructive sleep apnea (OSA) are at risk of sedation-related complications during diagnostic esophagogastroduodenoscopy (EGD).
A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 2010 and April 2011. The occurrence of cardiopulmonary complications related to sedation during diagnostic EGD was compared between OSA and control groups.
During the study period, 31 patients with OSA and 65 controls were enrolled. Compared with the control group, a higher dosage of midazolam was administered (P = 0.000) and a higher proportion of deep sedation was performed (P = 0.024) in the OSA group. However, all adverse events, including sedation failure, paradoxical responses, snoring or apnea, hypoxia, hypotension, oxygen or flumazenil administration, and other adverse events were not different between the two groups (all P > 0.1). Patients with OSA were not predisposed to hypoxia with multivariate logistic regression analysis (P = 0.068).
In patients with OSA, this limited sized study did not disclose an increased risk of cardiopulmonary complications during diagnostic EGD under sedation.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>23922472</pmid><doi>10.3748/wjg.v19.i29.4745</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Brief Case-Control Studies Chi-Square Distribution Deep Sedation - adverse effects Endoscopy, Digestive System - adverse effects Female Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - adverse effects Hypotension - etiology Hypoxia - etiology Logistic Models Male Midazolam - administration & dosage Midazolam - adverse effects Middle Aged Multivariate Analysis Odds Ratio Polysomnography Predictive Value of Tests Prospective Studies Respiratory Tract Diseases - etiology Risk Assessment Risk Factors Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - diagnosis |
| title | Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients |
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