The ADAS-Cog revisited: Novel composite scales based on ADAS-Cog to improve efficiency in MCI and early AD trials

Abstract Background The Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) has been used widely as a cognitive end point in Alzheimer’s Disease (AD) clinical trials. Efforts to treat AD pathology at earlier stages have also used ADAS-Cog, but failure in these trials can be difficult to interp...

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Veröffentlicht in:	Alzheimer's & dementia 2013-02, Vol.9 (1), p.S21-S31
Hauptverfasser:	Raghavan, Nandini, Samtani, Mahesh N, Farnum, Michael, Yang, Eric, Novak, Gerald, Grundman, Michael, Narayan, Vaibhav, DiBernardo, Allitia
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAS-Cog Aged Alzheimer Disease - diagnosis Alzheimer Disease - psychology Alzheimer's disease Ceiling effects Clinical trials Clinical Trials as Topic Cognitive Dysfunction - diagnosis Composite endpoints Early Diagnosis Female Humans Male MCI Mild cognitive impairment Neurology Neuropsychological Tests Novel endpoints Power Sample size
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