The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase‐independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5′‐dangling modified nucleotide. This mechanistic feature is distinct from DNA glycosylase‐m...

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Veröffentlicht in:	Nucleic acids research 2004-01, Vol.32 (1), p.73-81
Hauptverfasser:	Gros, Laurent, Ishchenko, Alexander A., Ide, Hiroshi, Elder, Rhoderick H., Saparbaev, Murat K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Extracts Cellular Biology DNA Damage DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism HeLa Cells Humans Kinetics Life Sciences Magnesium Magnesium - pharmacology Nucleotides Nucleotides - metabolism Oligodeoxyribonucleotides Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Oxidation-Reduction Protein Conformation Protein Conformation - drug effects Substrate Specificity
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