Funneling and frustration in the energy landscapes of some designed and simplified proteins

We explore the similarities and differences between the energy landscapes of proteins that have been selected by nature and those of some proteins designed by humans. Natural proteins have evolved to function as well as fold, and this is a source of energetic frustration. The sequence of Top7, on th...

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Veröffentlicht in:	The Journal of chemical physics 2013-09, Vol.139 (12), p.121908
Hauptverfasser:	Truong, Ha H, Kim, Bobby L, Schafer, Nicholas P, Wolynes, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Kinetics Models, Molecular Protein Conformation Protein Folding Proteins - chemistry Thermodynamics
Online-Zugang:	Volltext
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