Autism-specific maternal autoantibodies recognize critical proteins in developing brain
Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, s...
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| Veröffentlicht in: | Translational psychiatry 2013-07, Vol.3 (7), p.e277-e277 |
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| creator | Braunschweig, D Krakowiak, P Duncanson, P Boyce, R Hansen, R L Ashwood, P Hertz-Picciotto, I Pessah, I N Van de Water, J |
| description | Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls. ASD children from mothers with specific reactivity to LDH, STIP1 and CRMP1 and/or cypin (7% vs 0% in controls;
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| doi_str_mv | 10.1038/tp.2013.50 |
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P
<0.0002; odds ratios of 24.2 (95% confidence interval: 1.45–405)) had elevated stereotypical behaviors compared with ASD children from mothers lacking these antibodies. We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/tp.2013.50</identifier><identifier>PMID: 23838888</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/38 ; 631/378/2571 ; 692/420/2780/2152/2153/1291 ; 692/699/476/1312 ; Antibody Specificity - immunology ; Autistic Disorder - immunology ; Autoantibodies - immunology ; Behavioral Sciences ; Biological Psychology ; Blotting, Western ; Brain - growth & development ; Brain - immunology ; Child ; Electrophoresis, Gel, Two-Dimensional ; Female ; Guanine Deaminase - immunology ; Humans ; Intercellular Signaling Peptides and Proteins - immunology ; Isoenzymes - immunology ; L-Lactate Dehydrogenase - immunology ; Maternal-Fetal Exchange - immunology ; Medicine ; Medicine & Public Health ; Nerve Tissue Proteins - immunology ; Neurosciences ; Original ; original-article ; Pharmacotherapy ; Pregnancy ; Psychiatry ; Stereotyped Behavior ; Y-Box-Binding Protein 1 - immunology</subject><ispartof>Translational psychiatry, 2013-07, Vol.3 (7), p.e277-e277</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group Jul 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-60adeb467223e43ec88800442dcf8394625946191be7503ada36f2479a71b9a3</citedby><cites>FETCH-LOGICAL-c508t-60adeb467223e43ec88800442dcf8394625946191be7503ada36f2479a71b9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731784/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731784/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23838888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braunschweig, D</creatorcontrib><creatorcontrib>Krakowiak, P</creatorcontrib><creatorcontrib>Duncanson, P</creatorcontrib><creatorcontrib>Boyce, R</creatorcontrib><creatorcontrib>Hansen, R L</creatorcontrib><creatorcontrib>Ashwood, P</creatorcontrib><creatorcontrib>Hertz-Picciotto, I</creatorcontrib><creatorcontrib>Pessah, I N</creatorcontrib><creatorcontrib>Van de Water, J</creatorcontrib><title>Autism-specific maternal autoantibodies recognize critical proteins in developing brain</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>Transl Psychiatry</addtitle><description>Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls. ASD children from mothers with specific reactivity to LDH, STIP1 and CRMP1 and/or cypin (7% vs 0% in controls;
P
<0.0002; odds ratios of 24.2 (95% confidence interval: 1.45–405)) had elevated stereotypical behaviors compared with ASD children from mothers lacking these antibodies. We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism.</description><subject>631/250/38</subject><subject>631/378/2571</subject><subject>692/420/2780/2152/2153/1291</subject><subject>692/699/476/1312</subject><subject>Antibody Specificity - immunology</subject><subject>Autistic Disorder - immunology</subject><subject>Autoantibodies - immunology</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Blotting, Western</subject><subject>Brain - growth & development</subject><subject>Brain - immunology</subject><subject>Child</subject><subject>Electrophoresis, Gel, Two-Dimensional</subject><subject>Female</subject><subject>Guanine Deaminase - immunology</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - immunology</subject><subject>Isoenzymes - immunology</subject><subject>L-Lactate Dehydrogenase - immunology</subject><subject>Maternal-Fetal Exchange - immunology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerve Tissue Proteins - immunology</subject><subject>Neurosciences</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Pregnancy</subject><subject>Psychiatry</subject><subject>Stereotyped Behavior</subject><subject>Y-Box-Binding Protein 1 - immunology</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU9LxDAQxYMoKqsXP4AUvIjSNWnaJr0Ii_gPBC-Cx5Cm0xppk5qkC_rpzbIqq85hJjA_Xl7yEDoieE4w5RdhnGeY0HmBt9B-RgqeUsL59sZ5Dx16_4pjFTknjOyivYxyymPto-fFFLQfUj-C0q1WySADOCP7RE7BShN0bRsNPnGgbGf0ByTK6aBVJEZnA2jjE22SBpbQ21GbLqmd1OYA7bSy93D4NWfo6eb66eoufXi8vb9aPKSqwDykJZYN1HnJsoxCTkFFUxjnedaoltMqL7MiNlKRGliBqWwkLdssZ5VkpK4knaHLtew41QM0Ckxwshej04N078JKLX5vjH4RnV0KyihhPI8Cp18Czr5N4IMYtFfQ99KAnbwgtKoKzDghET35g77aafVVkWJVBHnBy0idrSnlrPcO2h8zBItVYiKMYpWYiO-ZoeNN-z_odz4ROF8DPq5MB27jzv9yn3PooFs</recordid><startdate>20130709</startdate><enddate>20130709</enddate><creator>Braunschweig, D</creator><creator>Krakowiak, P</creator><creator>Duncanson, P</creator><creator>Boyce, R</creator><creator>Hansen, R L</creator><creator>Ashwood, P</creator><creator>Hertz-Picciotto, I</creator><creator>Pessah, I N</creator><creator>Van de Water, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130709</creationdate><title>Autism-specific maternal autoantibodies recognize critical proteins in developing brain</title><author>Braunschweig, D ; 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We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls. ASD children from mothers with specific reactivity to LDH, STIP1 and CRMP1 and/or cypin (7% vs 0% in controls;
P
<0.0002; odds ratios of 24.2 (95% confidence interval: 1.45–405)) had elevated stereotypical behaviors compared with ASD children from mothers lacking these antibodies. We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23838888</pmid><doi>10.1038/tp.2013.50</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250/38 631/378/2571 692/420/2780/2152/2153/1291 692/699/476/1312 Antibody Specificity - immunology Autistic Disorder - immunology Autoantibodies - immunology Behavioral Sciences Biological Psychology Blotting, Western Brain - growth & development Brain - immunology Child Electrophoresis, Gel, Two-Dimensional Female Guanine Deaminase - immunology Humans Intercellular Signaling Peptides and Proteins - immunology Isoenzymes - immunology L-Lactate Dehydrogenase - immunology Maternal-Fetal Exchange - immunology Medicine Medicine & Public Health Nerve Tissue Proteins - immunology Neurosciences Original original-article Pharmacotherapy Pregnancy Psychiatry Stereotyped Behavior Y-Box-Binding Protein 1 - immunology |
| title | Autism-specific maternal autoantibodies recognize critical proteins in developing brain |
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