High blood pressure during pregnancy is associated with future cardiovascular disease: an observational cohort study
Objectives The study aimed to determine if having a hypertensive disorder of pregnancy (HDP) is a risk factor for future cardiovascular disease (CVD), independent of age and body mass index (BMI). Design Data were sourced from the baseline questionnaire of the 45 and Up Study, Australia, an observat...
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| description | Objectives The study aimed to determine if having a hypertensive disorder of pregnancy (HDP) is a risk factor for future cardiovascular disease (CVD), independent of age and body mass index (BMI). Design Data were sourced from the baseline questionnaire of the 45 and Up Study, Australia, an observational cohort study. Setting Participants were randomly selected from the Australian Medicare Database within New South Wales. Participants A total of 84 619 women were eligible for this study, of which 71 819 were included. These women had given birth between the ages of 18 and 45 years, had an intact uterus and ovaries, and had not been diagnosed with high blood pressure prior to their first pregnancy. Results HDP was associated with higher odds of having high blood pressure ( |
| doi_str_mv | 10.1136/bmjopen-2013-002964 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3731716</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4039200341</sourcerecordid><originalsourceid>FETCH-LOGICAL-b472t-4474a70fe115646be8dbe5f7f6871970e84625567b6585cc2966000a2130e42e3</originalsourceid><addsrcrecordid>eNqNkV1rFDEYhYMottT-AkEC3ngzNd-Z9UKQolYoeKPXIZN5ZzfLbLLmY8v-ezPsWqpXhkAS8pxDTg5Crym5oZSr98NuG_cQOkYo7whhKyWeoUtGhOgUkfL5k_0Fus55S9oQciUle4kuGO_7ZV6icufXGzzMMY54nyDnmgCPNfmwXs7rYIM7Yp-xzTk6bwuM-MGXDZ5qWVBn0-jjwWZXZ5vw6DPYDB-wDTgOGdLBFh-DnbGLm5gKzqWOx1foxWTnDNfn9Qr9_PL5x-1dd__967fbT_fdIDQrnRBaWE0moFQqoQboxwHkpCfVa7rSBHqhmJRKD0r20rn2CaqltIxyAoIBv0IfT777OuxgdBBKsrPZJ7-z6Wii9ebvm-A3Zh0PhmtONVXN4N3ZIMVfFXIxO58dzLMNEGs2VFBOFaVEN_TtP-g21tSSN0r3knOmetIofqJcijknmB4fQ4lZijXnYs1SrDkV21RvnuZ41PypsQE3J6Cp_8vxN5XlsMw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1785332680</pqid></control><display><type>article</type><title>High blood pressure during pregnancy is associated with future cardiovascular disease: an observational cohort study</title><source>BMJ Open Access Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Tooher, Jane ; Chiu, Christine L ; Yeung, Kristen ; Lupton, Samantha J ; Thornton, Charlene ; Makris, Angela ; O'Loughlin, Aiden ; Hennessy, Annemarie ; Lind, Joanne M</creator><creatorcontrib>Tooher, Jane ; Chiu, Christine L ; Yeung, Kristen ; Lupton, Samantha J ; Thornton, Charlene ; Makris, Angela ; O'Loughlin, Aiden ; Hennessy, Annemarie ; Lind, Joanne M</creatorcontrib><description><![CDATA[Objectives The study aimed to determine if having a hypertensive disorder of pregnancy (HDP) is a risk factor for future cardiovascular disease (CVD), independent of age and body mass index (BMI). Design Data were sourced from the baseline questionnaire of the 45 and Up Study, Australia, an observational cohort study. Setting Participants were randomly selected from the Australian Medicare Database within New South Wales. Participants A total of 84 619 women were eligible for this study, of which 71 819 were included. These women had given birth between the ages of 18 and 45 years, had an intact uterus and ovaries, and had not been diagnosed with high blood pressure prior to their first pregnancy. Results HDP was associated with higher odds of having high blood pressure (<58 years: adjusted OR 3.79, 99% CI 3.38 to 4.24; p<0.001 and ≥58 years: 2.83, 2.58 to 3.12; p<0.001) and stroke (<58 years: 1.69, 1.02 to 2.82; p=0.008 and ≥58 years: 1.46, 1.13 to 1.88; p<0.001) in later life. Women with HDP had a younger age of onset of high blood pressure (45.6 vs 54.8 years, p<0.001) and stroke (58 vs 62.5 years, p<0.001). Women who had HDP and whose present day BMI was <25 had significantly higher odds of having high blood pressure, compared with women who were normotensive during pregnancy (<58 years: 4.55, 3.63 to 5.71; p<0.001 and ≥58 years, 2.94, 2.49 to 3.47; p<0.001). Women who had HDP and a present day BMI≥25 had significantly increased odds of high blood pressure (<58 years: 12.48, 10.63 to 14.66; p<0.001 and ≥58 years, 5.16, 4.54 to 5.86; p<0.001), compared with healthy weight women with a normotensive pregnancy. Conclusions HDP is an independent risk factor for future CVD, and this risk is further exacerbated by the presence of overweight or obesity in later life.]]></description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2013-002964</identifier><identifier>PMID: 23883883</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Age ; Blood pressure ; Body mass index ; Cardiovascular disease ; Endothelium ; Heart ; Hypertension ; Insulin ; Insulin resistance ; Mortality ; Obesity ; Obstetrics and Gynaecology ; Placenta ; Preeclampsia ; Pregnancy ; Questionnaires ; Stroke ; Studies ; Womens health</subject><ispartof>BMJ open, 2013-01, Vol.3 (7), p.e002964</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2013 This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-4474a70fe115646be8dbe5f7f6871970e84625567b6585cc2966000a2130e42e3</citedby><cites>FETCH-LOGICAL-b472t-4474a70fe115646be8dbe5f7f6871970e84625567b6585cc2966000a2130e42e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmjopen.bmj.com/content/3/7/e002964.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmjopen.bmj.com/content/3/7/e002964.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27526,27527,27901,27902,53766,53768,77344,77375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23883883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tooher, Jane</creatorcontrib><creatorcontrib>Chiu, Christine L</creatorcontrib><creatorcontrib>Yeung, Kristen</creatorcontrib><creatorcontrib>Lupton, Samantha J</creatorcontrib><creatorcontrib>Thornton, Charlene</creatorcontrib><creatorcontrib>Makris, Angela</creatorcontrib><creatorcontrib>O'Loughlin, Aiden</creatorcontrib><creatorcontrib>Hennessy, Annemarie</creatorcontrib><creatorcontrib>Lind, Joanne M</creatorcontrib><title>High blood pressure during pregnancy is associated with future cardiovascular disease: an observational cohort study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description><![CDATA[Objectives The study aimed to determine if having a hypertensive disorder of pregnancy (HDP) is a risk factor for future cardiovascular disease (CVD), independent of age and body mass index (BMI). Design Data were sourced from the baseline questionnaire of the 45 and Up Study, Australia, an observational cohort study. Setting Participants were randomly selected from the Australian Medicare Database within New South Wales. Participants A total of 84 619 women were eligible for this study, of which 71 819 were included. These women had given birth between the ages of 18 and 45 years, had an intact uterus and ovaries, and had not been diagnosed with high blood pressure prior to their first pregnancy. Results HDP was associated with higher odds of having high blood pressure (<58 years: adjusted OR 3.79, 99% CI 3.38 to 4.24; p<0.001 and ≥58 years: 2.83, 2.58 to 3.12; p<0.001) and stroke (<58 years: 1.69, 1.02 to 2.82; p=0.008 and ≥58 years: 1.46, 1.13 to 1.88; p<0.001) in later life. Women with HDP had a younger age of onset of high blood pressure (45.6 vs 54.8 years, p<0.001) and stroke (58 vs 62.5 years, p<0.001). Women who had HDP and whose present day BMI was <25 had significantly higher odds of having high blood pressure, compared with women who were normotensive during pregnancy (<58 years: 4.55, 3.63 to 5.71; p<0.001 and ≥58 years, 2.94, 2.49 to 3.47; p<0.001). Women who had HDP and a present day BMI≥25 had significantly increased odds of high blood pressure (<58 years: 12.48, 10.63 to 14.66; p<0.001 and ≥58 years, 5.16, 4.54 to 5.86; p<0.001), compared with healthy weight women with a normotensive pregnancy. Conclusions HDP is an independent risk factor for future CVD, and this risk is further exacerbated by the presence of overweight or obesity in later life.]]></description><subject>Age</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Endothelium</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obstetrics and Gynaecology</subject><subject>Placenta</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Questionnaires</subject><subject>Stroke</subject><subject>Studies</subject><subject>Womens health</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV1rFDEYhYMottT-AkEC3ngzNd-Z9UKQolYoeKPXIZN5ZzfLbLLmY8v-ezPsWqpXhkAS8pxDTg5Crym5oZSr98NuG_cQOkYo7whhKyWeoUtGhOgUkfL5k_0Fus55S9oQciUle4kuGO_7ZV6icufXGzzMMY54nyDnmgCPNfmwXs7rYIM7Yp-xzTk6bwuM-MGXDZ5qWVBn0-jjwWZXZ5vw6DPYDB-wDTgOGdLBFh-DnbGLm5gKzqWOx1foxWTnDNfn9Qr9_PL5x-1dd__967fbT_fdIDQrnRBaWE0moFQqoQboxwHkpCfVa7rSBHqhmJRKD0r20rn2CaqltIxyAoIBv0IfT777OuxgdBBKsrPZJ7-z6Wii9ebvm-A3Zh0PhmtONVXN4N3ZIMVfFXIxO58dzLMNEGs2VFBOFaVEN_TtP-g21tSSN0r3knOmetIofqJcijknmB4fQ4lZijXnYs1SrDkV21RvnuZ41PypsQE3J6Cp_8vxN5XlsMw</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Tooher, Jane</creator><creator>Chiu, Christine L</creator><creator>Yeung, Kristen</creator><creator>Lupton, Samantha J</creator><creator>Thornton, Charlene</creator><creator>Makris, Angela</creator><creator>O'Loughlin, Aiden</creator><creator>Hennessy, Annemarie</creator><creator>Lind, Joanne M</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>High blood pressure during pregnancy is associated with future cardiovascular disease: an observational cohort study</title><author>Tooher, Jane ; Chiu, Christine L ; Yeung, Kristen ; Lupton, Samantha J ; Thornton, Charlene ; Makris, Angela ; O'Loughlin, Aiden ; Hennessy, Annemarie ; Lind, Joanne M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-4474a70fe115646be8dbe5f7f6871970e84625567b6585cc2966000a2130e42e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Endothelium</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obstetrics and Gynaecology</topic><topic>Placenta</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Questionnaires</topic><topic>Stroke</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tooher, Jane</creatorcontrib><creatorcontrib>Chiu, Christine L</creatorcontrib><creatorcontrib>Yeung, Kristen</creatorcontrib><creatorcontrib>Lupton, Samantha J</creatorcontrib><creatorcontrib>Thornton, Charlene</creatorcontrib><creatorcontrib>Makris, Angela</creatorcontrib><creatorcontrib>O'Loughlin, Aiden</creatorcontrib><creatorcontrib>Hennessy, Annemarie</creatorcontrib><creatorcontrib>Lind, Joanne M</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tooher, Jane</au><au>Chiu, Christine L</au><au>Yeung, Kristen</au><au>Lupton, Samantha J</au><au>Thornton, Charlene</au><au>Makris, Angela</au><au>O'Loughlin, Aiden</au><au>Hennessy, Annemarie</au><au>Lind, Joanne M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High blood pressure during pregnancy is associated with future cardiovascular disease: an observational cohort study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>3</volume><issue>7</issue><spage>e002964</spage><pages>e002964-</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract><![CDATA[Objectives The study aimed to determine if having a hypertensive disorder of pregnancy (HDP) is a risk factor for future cardiovascular disease (CVD), independent of age and body mass index (BMI). Design Data were sourced from the baseline questionnaire of the 45 and Up Study, Australia, an observational cohort study. Setting Participants were randomly selected from the Australian Medicare Database within New South Wales. Participants A total of 84 619 women were eligible for this study, of which 71 819 were included. These women had given birth between the ages of 18 and 45 years, had an intact uterus and ovaries, and had not been diagnosed with high blood pressure prior to their first pregnancy. Results HDP was associated with higher odds of having high blood pressure (<58 years: adjusted OR 3.79, 99% CI 3.38 to 4.24; p<0.001 and ≥58 years: 2.83, 2.58 to 3.12; p<0.001) and stroke (<58 years: 1.69, 1.02 to 2.82; p=0.008 and ≥58 years: 1.46, 1.13 to 1.88; p<0.001) in later life. Women with HDP had a younger age of onset of high blood pressure (45.6 vs 54.8 years, p<0.001) and stroke (58 vs 62.5 years, p<0.001). Women who had HDP and whose present day BMI was <25 had significantly higher odds of having high blood pressure, compared with women who were normotensive during pregnancy (<58 years: 4.55, 3.63 to 5.71; p<0.001 and ≥58 years, 2.94, 2.49 to 3.47; p<0.001). Women who had HDP and a present day BMI≥25 had significantly increased odds of high blood pressure (<58 years: 12.48, 10.63 to 14.66; p<0.001 and ≥58 years, 5.16, 4.54 to 5.86; p<0.001), compared with healthy weight women with a normotensive pregnancy. Conclusions HDP is an independent risk factor for future CVD, and this risk is further exacerbated by the presence of overweight or obesity in later life.]]></abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>23883883</pmid><doi>10.1136/bmjopen-2013-002964</doi><oa>free_for_read</oa></addata></record> |
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| source | BMJ Open Access Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Age Blood pressure Body mass index Cardiovascular disease Endothelium Heart Hypertension Insulin Insulin resistance Mortality Obesity Obstetrics and Gynaecology Placenta Preeclampsia Pregnancy Questionnaires Stroke Studies Womens health |
| title | High blood pressure during pregnancy is associated with future cardiovascular disease: an observational cohort study |
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