Semaphorin 5A Promotes Gastric Cancer Invasion/Metastasis via Urokinase-Type Plasminogen Activator/Phosphoinositide 3-Kinase/Protein Kinase B

Background Semaphorin 5A, a member of the semaphorin family, was originally identified as an axonal guidance factor functioning during neuronal development. Previously, we showed that the expression of semaphorin 5A might contribute to the metastasis of gastric cancer. However, less information is c...

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Veröffentlicht in:	Digestive diseases and sciences 2013-08, Vol.58 (8), p.2197-2204
Hauptverfasser:	Pan, Guoqing, Zhu, Zhu, Huang, Jian, Yang, Chenggang, Yang, Ying, Wang, Yingxia, Tuo, Xiaoyu, Su, Guomiao, Zhang, Xiangling, Yang, Zhi, Liu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cancer Cell Line, Tumor Cellular signal transduction Female Gastroenterology Gene Expression Regulation, Neoplastic - physiology Health aspects Hepatology Humans Medicine Medicine & Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Metastasis Mice Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Neoplasms, Experimental Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oncology Original Original Article Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Stomach cancer Stomach Neoplasms - metabolism Transplant Surgery Up-Regulation Urokinase Urokinase-Type Plasminogen Activator - genetics Urokinase-Type Plasminogen Activator - metabolism
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