BLM dissolvasome in DNA replication and repair

RecQ DNA helicases are critical for proper maintenance of genomic stability, and mutations in multiple human RecQ genes are linked with genetic disorders characterized by a predisposition to cancer. RecQ proteins are conserved from prokaryotes to humans and in all cases form higher-order complexes w...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2013-11, Vol.70 (21), p.4067-4084
Hauptverfasser:	Manthei, Kelly A, Keck, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase anemia Animals Biochemistry Biomedical and Life Sciences Biomedicine Bloom Syndrome - genetics Cancer Cell Biology complexing Deoxyribonucleic acid DNA DNA - genetics DNA Damage DNA helicases DNA Repair DNA Replication Fanconi Anemia - genetics genes genetic disorders genetic recombination genomes Genomic Instability Genomics Humans Life Sciences maintenance Mutation prokaryotic cells Protein Structure, Tertiary Proteins RecQ Helicases - genetics RecQ Helicases - metabolism RecQ Helicases - physiology Review somatic cells
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