Therapeutic Targeting of PELP1 Prevents Ovarian Cancer Growth and Metastasis

Ovarian cancer remains a major threat to women's health, partly due to difficulty in early diagnosis and development of metastases. A critical need exists to identify novel targets that curb the progression and metastasis of ovarian cancer. In this study, we examined whether the nuclear recepto...

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Veröffentlicht in:	Clinical cancer research 2011-04, Vol.17 (8), p.2250-2259
Hauptverfasser:	CHAKRAVARTY, Dimple, SAHA ROY, Sudipa, RAM BABU, Challa, DANDAMUDI, Rajasekhar, CURIEL, Tyler J, VIVAS-MEJIA, Pablo, LOPEZ-BERESTEIN, Gabriel, SOOD, Anil K, VADLAMUDI, Ratna K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Blotting, Western Cell Line, Tumor Cell Proliferation Co-Repressor Proteins - genetics Co-Repressor Proteins - metabolism Cytoskeleton - metabolism Female Female genital diseases Gene Expression Profiling Gynecology. Andrology. Obstetrics Humans Liposomes - administration & dosage Liposomes - chemistry Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical sciences Mice Mice, Nude Neoplasm Metastasis Oligonucleotide Array Sequence Analysis Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Pharmacology. Drug treatments Phosphatidylcholines - chemistry Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - chemistry RNA, Small Interfering - genetics Transcription Factors - genetics Transcription Factors - metabolism Tumor Burden Tumors Xenograft Model Antitumor Assays
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