Sox9 Induction, Ectopic Paneth Cells, and Mitotic Spindle Axis Defects in Mouse Colon Adenomatous Epithelium Arising From Conditional Biallelic Apc Inactivation

We generated transgenic mice in which human CDX2 gene elements control expression of a tamoxifen-regulated Cre protein ( CDX2P-CreER T2 ) to allow for inducible gene targeting in intestinal epithelium. After tamoxifen dosing of CDX2P-CreER T2 mice, Cre activity was detected in the distal ileal, ceca...

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Veröffentlicht in:	The American journal of pathology 2013-08, Vol.183 (2), p.493-503
Hauptverfasser:	Feng, Ying, Sentani, Kazuhiro, Wiese, Alexandra, Sands, Evan, Green, Maranne, Bommer, Guido T, Cho, Kathleen R, Fearon, Eric R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Animals CDX2 Transcription Factor Gene Silencing - physiology Genes, APC - physiology Homeodomain Proteins - genetics Humans Intestinal Mucosa - metabolism Mice Mice, Transgenic Paneth Cells - metabolism Pathology Regular SOX9 Transcription Factor - metabolism Spindle Apparatus - physiology Tamoxifen - pharmacology Transcription Factors - genetics Transgenes - genetics
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