Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [124I]-Morpholino-IPQA

Mutations in the kinase domain of epidermal growth factor receptor (EGFR) have high levels of basal receptor phosphorylation and are associated with clinical responsiveness to Iressa in patients with nonsmall cell lung cancer (NSCLC). This study aimed to assess the feasibility of morpholino-[124I]IP...

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Veröffentlicht in:	BioMed research international 2013-01, Vol.2013 (2013), p.1-10
Hauptverfasser:	Liu, Ren-Shyan, Hsieh, Ya-Ju, Wang, Hsin-Ell, Kong, Fanlin, Lin, Chien-Feng, Yeh, Skye Hsin-Hsien, Gelovani, Juri G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation Chemotherapy Clinical trials Gene Expression Regulation, Neoplastic Hospitals Humans Kinases Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical imaging Mice Molecular Imaging Mutation Nuclear medicine Phosphorylation Positron-Emission Tomography Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Research Article Rodents Tumors Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
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