Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers

The binding of transcription factors (TFs) to their specific motifs in genomic regulatory regions is commonly studied in isolation. However, in order to elucidate the mechanisms of transcriptional regulation, it is essential to determine which TFs bind DNA cooperatively as dimers and to infer the pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genome research 2013-08, Vol.23 (8), p.1307-1318
Hauptverfasser:	Jankowski, Aleksander, Szczurek, Ewa, Jauch, Ralf, Tiuryn, Jerzy, Prabhakar, Shyam
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Base Sequence Binding Sites Cell Line, Tumor Cluster Analysis Computer Simulation Consensus Sequence Deoxyribonuclease I - chemistry DNA Cleavage Evolution, Molecular Hepatocyte Nuclear Factor 3-alpha - metabolism Humans Method Models, Biological Protein Binding Protein Interaction Mapping Protein Interaction Maps Protein Multimerization Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!