Small-molecule delivery by nanoparticles for anticancer therapy
Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxi...
Gespeichert in:
| Veröffentlicht in: | Trends in molecular medicine 2010-12, Vol.16 (12), p.594-602 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 602 |
|---|---|
| container_issue | 12 |
| container_start_page | 594 |
| container_title | Trends in molecular medicine |
| container_volume | 16 |
| creator | Chen, Zhuo (Georgia) |
| description | Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity. Current research in this field focuses on understanding precisely how small molecules are released from nanoparticles and delivered to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field. |
| doi_str_mv | 10.1016/j.molmed.2010.08.001 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3729441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1471491410001139</els_id><sourcerecordid>S1471491410001139</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-fe4117129fb446aed41d279f57ee514e295793bd5c31ad551fb8f7221c5f56583</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxi0Eov94gwrlBbL1OPY6voBQBbRSJQ4FidvIccatF2-ysrMr5e3xaunScuHk8Xi-bzy_YewS-AI4LK9Wi_UY19QvBC8p3i44h1fsFKSGWhrz8_UxBnnCznJelQKldfuWnQjeyqXh6pR9vF_bGOtiRW4bqeophh2luermarDDuLFpCi5SrvyYKjuUix0cpWp6pGQ38wV7423M9O7Pec5-fPn8_fqmvvv29fb6013tFOip9iQBNAjjOymXlnoJvdDGK02kQJIwSpum65VrwPZKge9ar4UAp7xaqrY5Zx8OvpttV4Z2NEzJRtyksLZpxtEGfPkyhEd8GHfYaGGkhGIgDwYujTkn8kctcNwDxRUegOIeKPIWC68ie_-871H0RPDvx6hMvwuUMLtABVEfErkJ-zH8r8O_Bi6GoWCOv2imvBq3aShkETAL5Hi_X-p-p8CLGhrT_AYZ7p90</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Small-molecule delivery by nanoparticles for anticancer therapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Chen, Zhuo (Georgia)</creator><creatorcontrib>Chen, Zhuo (Georgia)</creatorcontrib><description>Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity. Current research in this field focuses on understanding precisely how small molecules are released from nanoparticles and delivered to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field.</description><identifier>ISSN: 1471-4914</identifier><identifier>EISSN: 1471-499X</identifier><identifier>DOI: 10.1016/j.molmed.2010.08.001</identifier><identifier>PMID: 20846905</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - therapeutic use ; Drug Delivery Systems - instrumentation ; Drug Delivery Systems - methods ; Humans ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanotechnology - instrumentation ; Nanotechnology - methods ; Neoplasms - drug therapy ; Pathology</subject><ispartof>Trends in molecular medicine, 2010-12, Vol.16 (12), p.594-602</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><rights>2010 Elsevier Ltd. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-fe4117129fb446aed41d279f57ee514e295793bd5c31ad551fb8f7221c5f56583</citedby><cites>FETCH-LOGICAL-c517t-fe4117129fb446aed41d279f57ee514e295793bd5c31ad551fb8f7221c5f56583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1471491410001139$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20846905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhuo (Georgia)</creatorcontrib><title>Small-molecule delivery by nanoparticles for anticancer therapy</title><title>Trends in molecular medicine</title><addtitle>Trends Mol Med</addtitle><description>Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity. Current research in this field focuses on understanding precisely how small molecules are released from nanoparticles and delivered to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field.</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Delivery Systems - methods</subject><subject>Humans</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Nanotechnology - instrumentation</subject><subject>Nanotechnology - methods</subject><subject>Neoplasms - drug therapy</subject><subject>Pathology</subject><issn>1471-4914</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0Eov94gwrlBbL1OPY6voBQBbRSJQ4FidvIccatF2-ysrMr5e3xaunScuHk8Xi-bzy_YewS-AI4LK9Wi_UY19QvBC8p3i44h1fsFKSGWhrz8_UxBnnCznJelQKldfuWnQjeyqXh6pR9vF_bGOtiRW4bqeophh2luermarDDuLFpCi5SrvyYKjuUix0cpWp6pGQ38wV7423M9O7Pec5-fPn8_fqmvvv29fb6013tFOip9iQBNAjjOymXlnoJvdDGK02kQJIwSpum65VrwPZKge9ar4UAp7xaqrY5Zx8OvpttV4Z2NEzJRtyksLZpxtEGfPkyhEd8GHfYaGGkhGIgDwYujTkn8kctcNwDxRUegOIeKPIWC68ie_-871H0RPDvx6hMvwuUMLtABVEfErkJ-zH8r8O_Bi6GoWCOv2imvBq3aShkETAL5Hi_X-p-p8CLGhrT_AYZ7p90</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Chen, Zhuo (Georgia)</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20101201</creationdate><title>Small-molecule delivery by nanoparticles for anticancer therapy</title><author>Chen, Zhuo (Georgia)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-fe4117129fb446aed41d279f57ee514e295793bd5c31ad551fb8f7221c5f56583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drug Delivery Systems - methods</topic><topic>Humans</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - therapeutic use</topic><topic>Nanotechnology - instrumentation</topic><topic>Nanotechnology - methods</topic><topic>Neoplasms - drug therapy</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhuo (Georgia)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhuo (Georgia)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-molecule delivery by nanoparticles for anticancer therapy</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>16</volume><issue>12</issue><spage>594</spage><epage>602</epage><pages>594-602</pages><issn>1471-4914</issn><eissn>1471-499X</eissn><abstract>Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity. Current research in this field focuses on understanding precisely how small molecules are released from nanoparticles and delivered to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20846905</pmid><doi>10.1016/j.molmed.2010.08.001</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-4914 |
| ispartof | Trends in molecular medicine, 2010-12, Vol.16 (12), p.594-602 |
| issn | 1471-4914 1471-499X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3729441 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Humans Nanoparticles - chemistry Nanoparticles - therapeutic use Nanotechnology - instrumentation Nanotechnology - methods Neoplasms - drug therapy Pathology |
| title | Small-molecule delivery by nanoparticles for anticancer therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A16%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Small-molecule%20delivery%20by%20nanoparticles%20for%20anticancer%20therapy&rft.jtitle=Trends%20in%20molecular%20medicine&rft.au=Chen,%20Zhuo%20(Georgia)&rft.date=2010-12-01&rft.volume=16&rft.issue=12&rft.spage=594&rft.epage=602&rft.pages=594-602&rft.issn=1471-4914&rft.eissn=1471-499X&rft_id=info:doi/10.1016/j.molmed.2010.08.001&rft_dat=%3Celsevier_pubme%3ES1471491410001139%3C/elsevier_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/20846905&rft_els_id=S1471491410001139&rfr_iscdi=true |