A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

The mTOR complex 1 (mTORC1) pathway promotes cell growth in response to many cues, including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to promote mTORC1 translocation to the lysosomal surface, its site of activation. Although progress has been made in identifying pos...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-05, Vol.340 (6136), p.1100-1106
Hauptverfasser:	Bar-Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew D., Chen, Walter W., Ottina, Kathleen A., Grabiner, Brian C., Spear, Eric D., Carter, Scott L, Meyerson, Matthew, Sabatini, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - metabolism B lymphocytes Cancer Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism cell growth Cell Line, Tumor Cell lines Cellular immunity Constraining Delta cells diabetes Government regulations GTPase-Activating Proteins guanosinetriphosphatase HEK293 Cells HeLa cells HT29 cells Humans Immunoblotting Inhibition Kinases Lysosomes - enzymology Mechanistic Target of Rapamycin Complex 1 metabolism Monomeric GTP-Binding Proteins - metabolism Multiprotein Complexes Mutation neoplasms Neoplasms - enzymology Neoplasms - genetics Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism protein kinases Proteins Proteins - metabolism Ragas RNA, Small Interfering - genetics Signal transduction Strategy T lymphocytes TOR Serine-Threonine Kinases Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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