Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)
Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with t...
Gespeichert in:
| Veröffentlicht in: | Current opinion in solid state & materials science 2012-12, Vol.16 (6), p.323-332 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 332 |
|---|---|
| container_issue | 6 |
| container_start_page | 323 |
| container_title | Current opinion in solid state & materials science |
| container_volume | 16 |
| creator | Tong, Rong Gabrielson, Nathan P. Fan, Timothy M. Cheng, Jianjun |
| description | Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer–drug conjugates and nanoconjugates. |
| doi_str_mv | 10.1016/j.cossms.2013.01.001 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3728009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1359028613000028</els_id><sourcerecordid>S1359028613000028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-584bea305087aef8b4c0b2bc93fd37d6b6604d371871f90cc1278f878a2488443</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwBwhlCYuEcew6zgYJVbykIljA2nImTnGV2lUcKvXvcVUodMPKV75z53EIOaeQUaDiep6hD2ERshwoy4BmAPSADKksyhQYl4dRs3HUuRQDchLCHAC4EOKYDHJWUh7dIXl-9e16YTqLidPOL0xt0ToTkkoHUyfeJctYcNlq7G1trhLt6r2fFH06a9fo2419So4a3QZz9v2OyPv93dvkMZ2-PDxNbqcpcin7dCx5ZTSDMchCm0ZWHKHKKyxZU7OiFpUQwKOKt9CmBESaF7KRhdR5zHPORuRm23f5WcWV0bi-061adnahu7Xy2qp9x9kPNfMrxYpcApSxAd82wC5C7Eyzy1JQG7xqrrZ41QavAqoi3hi7-Dt3F_rh-buYidevrOlUQGscRqydwV7V3v4_4QuYqY8X</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)</title><source>Elsevier ScienceDirect Journals</source><creator>Tong, Rong ; Gabrielson, Nathan P. ; Fan, Timothy M. ; Cheng, Jianjun</creator><creatorcontrib>Tong, Rong ; Gabrielson, Nathan P. ; Fan, Timothy M. ; Cheng, Jianjun</creatorcontrib><description>Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer–drug conjugates and nanoconjugates.</description><identifier>ISSN: 1359-0286</identifier><identifier>EISSN: 1879-0348</identifier><identifier>DOI: 10.1016/j.cossms.2013.01.001</identifier><identifier>PMID: 23914135</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cancer ; Chemotherapeutics ; Drug delivery ; Nanoconjugates ; Nanomedicine ; PLA ; PLGA ; Polymer–drug conjugates</subject><ispartof>Current opinion in solid state & materials science, 2012-12, Vol.16 (6), p.323-332</ispartof><rights>2013 Elsevier Ltd</rights><rights>2013 Elsevier Ltd. All rights reserved 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-584bea305087aef8b4c0b2bc93fd37d6b6604d371871f90cc1278f878a2488443</citedby><cites>FETCH-LOGICAL-c488t-584bea305087aef8b4c0b2bc93fd37d6b6604d371871f90cc1278f878a2488443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cossms.2013.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23914135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Rong</creatorcontrib><creatorcontrib>Gabrielson, Nathan P.</creatorcontrib><creatorcontrib>Fan, Timothy M.</creatorcontrib><creatorcontrib>Cheng, Jianjun</creatorcontrib><title>Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)</title><title>Current opinion in solid state & materials science</title><addtitle>Curr Opin Solid State Mater Sci</addtitle><description>Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer–drug conjugates and nanoconjugates.</description><subject>Cancer</subject><subject>Chemotherapeutics</subject><subject>Drug delivery</subject><subject>Nanoconjugates</subject><subject>Nanomedicine</subject><subject>PLA</subject><subject>PLGA</subject><subject>Polymer–drug conjugates</subject><issn>1359-0286</issn><issn>1879-0348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwBwhlCYuEcew6zgYJVbykIljA2nImTnGV2lUcKvXvcVUodMPKV75z53EIOaeQUaDiep6hD2ERshwoy4BmAPSADKksyhQYl4dRs3HUuRQDchLCHAC4EOKYDHJWUh7dIXl-9e16YTqLidPOL0xt0ToTkkoHUyfeJctYcNlq7G1trhLt6r2fFH06a9fo2419So4a3QZz9v2OyPv93dvkMZ2-PDxNbqcpcin7dCx5ZTSDMchCm0ZWHKHKKyxZU7OiFpUQwKOKt9CmBESaF7KRhdR5zHPORuRm23f5WcWV0bi-061adnahu7Xy2qp9x9kPNfMrxYpcApSxAd82wC5C7Eyzy1JQG7xqrrZ41QavAqoi3hi7-Dt3F_rh-buYidevrOlUQGscRqydwV7V3v4_4QuYqY8X</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Tong, Rong</creator><creator>Gabrielson, Nathan P.</creator><creator>Fan, Timothy M.</creator><creator>Cheng, Jianjun</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20121201</creationdate><title>Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)</title><author>Tong, Rong ; Gabrielson, Nathan P. ; Fan, Timothy M. ; Cheng, Jianjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-584bea305087aef8b4c0b2bc93fd37d6b6604d371871f90cc1278f878a2488443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cancer</topic><topic>Chemotherapeutics</topic><topic>Drug delivery</topic><topic>Nanoconjugates</topic><topic>Nanomedicine</topic><topic>PLA</topic><topic>PLGA</topic><topic>Polymer–drug conjugates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Rong</creatorcontrib><creatorcontrib>Gabrielson, Nathan P.</creatorcontrib><creatorcontrib>Fan, Timothy M.</creatorcontrib><creatorcontrib>Cheng, Jianjun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in solid state & materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Rong</au><au>Gabrielson, Nathan P.</au><au>Fan, Timothy M.</au><au>Cheng, Jianjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)</atitle><jtitle>Current opinion in solid state & materials science</jtitle><addtitle>Curr Opin Solid State Mater Sci</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>16</volume><issue>6</issue><spage>323</spage><epage>332</epage><pages>323-332</pages><issn>1359-0286</issn><eissn>1879-0348</eissn><abstract>Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer–drug conjugates and nanoconjugates.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23914135</pmid><doi>10.1016/j.cossms.2013.01.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-0286 |
| ispartof | Current opinion in solid state & materials science, 2012-12, Vol.16 (6), p.323-332 |
| issn | 1359-0286 1879-0348 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3728009 |
| source | Elsevier ScienceDirect Journals |
| subjects | Cancer Chemotherapeutics Drug delivery Nanoconjugates Nanomedicine PLA PLGA Polymer–drug conjugates |
| title | Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T03%3A53%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polymeric%20nanomedicines%20based%20on%20poly(lactide)%20and%20poly(lactide-co-glycolide)&rft.jtitle=Current%20opinion%20in%20solid%20state%20&%20materials%20science&rft.au=Tong,%20Rong&rft.date=2012-12-01&rft.volume=16&rft.issue=6&rft.spage=323&rft.epage=332&rft.pages=323-332&rft.issn=1359-0286&rft.eissn=1879-0348&rft_id=info:doi/10.1016/j.cossms.2013.01.001&rft_dat=%3Celsevier_pubme%3ES1359028613000028%3C/elsevier_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23914135&rft_els_id=S1359028613000028&rfr_iscdi=true |