Pharmacokinetic/Pharmacodynamic Modeling of Corticosterone Suppression and Lymphocytopenia by Methylprednisolone in Rats

Adrenal suppression and lymphocytopenia are commonly monitored pharmacological responses during systemic exposure to exogenously administered corticosteroids. The pharmacodynamics of plasma corticosterone (CS) and blood lymphocytes were investigated in 60 normal rats which received either 50 mg/kg m...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2008-07, Vol.97 (7), p.2820-2832
Hauptverfasser:	Yao, Zhenling, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cell trafficking Chromatography, High Pressure Liquid Circadian Rhythm corticosteroid Corticosterone - blood General pharmacology Glucocorticoids - adverse effects Glucocorticoids - pharmacokinetics Glucocorticoids - pharmacology hormones indirect response model Injections, Intramuscular lymphocyte Lymphocyte Count Lymphocytes - cytology Lymphopenia - blood Lymphopenia - chemically induced Male mathematical model Medical sciences Methylprednisolone - adverse effects Methylprednisolone - pharmacokinetics Methylprednisolone - pharmacology Models, Biological Pharmaceutical technology. Pharmaceutical industry pharmacodynamics pharmacokinetic/pharmacodynamic models pharmacokinetics Pharmacology. Drug treatments Rats Rats, Wistar
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