Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus

Methamphetamine is currently one of the most widely abused drugs worldwide, with hyperthermia being a leading cause of death in methamphetamine overdose situations. Methamphetamine-induced hyperthermia involves a variety of cellular mechanisms, including increases in hypothalamic interleukin-1 beta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2012-09, Vol.691 (1-3), p.103-109
Hauptverfasser:	Seminerio, Michael J., Robson, Matthew J., McCurdy, Christopher R., Matsumoto, Rae R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Temperature - drug effects Dose-Response Relationship, Drug Fever - chemically induced Fever - drug therapy Fever - genetics Fever - physiopathology Gene Expression Regulation - drug effects Hyperthermia Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus - physiopathology Interleukin-1beta - genetics Interleukin-1β Male Methamphetamine Methamphetamine - toxicity Mice Neurotoxins - toxicity Piperazines - chemistry Piperazines - pharmacology Piperazines - therapeutic use Receptors, sigma - antagonists & inhibitors Reproducibility of Results RNA, Messenger - genetics RNA, Messenger - metabolism Sigma receptor Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!