Morphine-Induced Epidermal Growth Factor Pathway Activation in Non–Small Cell Lung Cancer

Epidermal growth factor receptor (EGFR) is coactivated by the μ-opioid receptor (MOR), expressed on non-small cell lung cancer (NSCLC) cells and human lung cancer. We hypothesized that clinically used opioid analgesics that are MOR agonists coactivate EGFR, resulting in growth- and survival-promotin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Anesthesia and analgesia 2011-12, Vol.113 (6), p.1353-1364
Hauptverfasser:	Fujioka, Naomi, Nguyen, Julia, Chen, Chunsheng, Li, Yunfang, Pasrija, Teena, Niehans, Gloria, Johnson, Katherine N., Gupta, Vinita, Kratzke, Robert A., Gupta, Kalpna
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Carcinoma, Non-Small-Cell Lung - enzymology Cell Line, Transformed Cell Line, Tumor Epidermal Growth Factor - metabolism Epidermal Growth Factor - physiology Erlotinib Hydrochloride Humans Lung Neoplasms - enzymology Lung Neoplasms - metabolism MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical sciences Morphine - pharmacology Quinazolines - pharmacology Receptor, Epidermal Growth Factor - metabolism Receptor, Epidermal Growth Factor - physiology Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!