Population genomics of post-vaccine changes in pneumococcal epidemiology
Nicholas Croucher and colleagues report whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae , a major cause of pneumonia, bacteremia and meningitis. They examine the impact of the introduction of the pneumococcal conjugate vaccine PCV7 on pneumococcal population dynamics...
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| Veröffentlicht in: | Nature genetics 2013-06, Vol.45 (6), p.656-663 |
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| creator | Croucher, Nicholas J Finkelstein, Jonathan A Pelton, Stephen I Mitchell, Patrick K Lee, Grace M Parkhill, Julian Bentley, Stephen D Hanage, William P Lipsitch, Marc |
| description | Nicholas Croucher and colleagues report whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
, a major cause of pneumonia, bacteremia and meningitis. They examine the impact of the introduction of the pneumococcal conjugate vaccine PCV7 on pneumococcal population dynamics.
Whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction. |
| doi_str_mv | 10.1038/ng.2625 |
| format | Article |
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Streptococcus pneumoniae
, a major cause of pneumonia, bacteremia and meningitis. They examine the impact of the introduction of the pneumococcal conjugate vaccine PCV7 on pneumococcal population dynamics.
Whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng.2625</identifier><identifier>PMID: 23644493</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/325 ; Agriculture ; Analysis ; Animal Genetics and Genomics ; Bacterial pneumonia ; Biomedicine ; Cancer Research ; Causes of ; Child ; Disease ; Drug resistance ; Drug Resistance, Bacterial - genetics ; Epidemiology ; Gene Frequency ; Gene Function ; Genetic aspects ; Genetic diversity ; Genetic Variation ; Genome, Bacterial ; Genomes ; Genotype ; Genotypes ; Health aspects ; Human Genetics ; Humans ; Mass Vaccination ; Metagenomics ; Methods ; Models, Genetic ; Multigene Family ; Mutation ; Phylogeny ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines ; Pneumonia ; Population genetics ; Prevalence ; Prevention ; Software ; Streptococcus infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - genetics ; Streptococcus pneumoniae - immunology ; United States - epidemiology ; Vaccines</subject><ispartof>Nature genetics, 2013-06, Vol.45 (6), p.656-663</ispartof><rights>Springer Nature America, Inc. 2013</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c664t-c6a707bb408b1408dbde8b53a6ec5e2e50bbdf216beff9faf31c469e2b992e313</citedby><cites>FETCH-LOGICAL-c664t-c6a707bb408b1408dbde8b53a6ec5e2e50bbdf216beff9faf31c469e2b992e313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng.2625$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng.2625$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23644493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Croucher, Nicholas J</creatorcontrib><creatorcontrib>Finkelstein, Jonathan A</creatorcontrib><creatorcontrib>Pelton, Stephen I</creatorcontrib><creatorcontrib>Mitchell, Patrick K</creatorcontrib><creatorcontrib>Lee, Grace M</creatorcontrib><creatorcontrib>Parkhill, Julian</creatorcontrib><creatorcontrib>Bentley, Stephen D</creatorcontrib><creatorcontrib>Hanage, William P</creatorcontrib><creatorcontrib>Lipsitch, Marc</creatorcontrib><title>Population genomics of post-vaccine changes in pneumococcal epidemiology</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Nicholas Croucher and colleagues report whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
, a major cause of pneumonia, bacteremia and meningitis. They examine the impact of the introduction of the pneumococcal conjugate vaccine PCV7 on pneumococcal population dynamics.
Whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction.</description><subject>631/208/325</subject><subject>Agriculture</subject><subject>Analysis</subject><subject>Animal Genetics and Genomics</subject><subject>Bacterial pneumonia</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Causes of</subject><subject>Child</subject><subject>Disease</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Epidemiology</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Mass Vaccination</subject><subject>Metagenomics</subject><subject>Methods</subject><subject>Models, Genetic</subject><subject>Multigene Family</subject><subject>Mutation</subject><subject>Phylogeny</subject><subject>Pneumococcal Infections - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Croucher, Nicholas J</au><au>Finkelstein, Jonathan A</au><au>Pelton, Stephen I</au><au>Mitchell, Patrick K</au><au>Lee, Grace M</au><au>Parkhill, Julian</au><au>Bentley, Stephen D</au><au>Hanage, William P</au><au>Lipsitch, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Population genomics of post-vaccine changes in pneumococcal epidemiology</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>45</volume><issue>6</issue><spage>656</spage><epage>663</epage><pages>656-663</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><abstract>Nicholas Croucher and colleagues report whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
, a major cause of pneumonia, bacteremia and meningitis. They examine the impact of the introduction of the pneumococcal conjugate vaccine PCV7 on pneumococcal population dynamics.
Whole-genome sequencing of 616 asymptomatically carried
Streptococcus pneumoniae
isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>23644493</pmid><doi>10.1038/ng.2625</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 631/208/325 Agriculture Analysis Animal Genetics and Genomics Bacterial pneumonia Biomedicine Cancer Research Causes of Child Disease Drug resistance Drug Resistance, Bacterial - genetics Epidemiology Gene Frequency Gene Function Genetic aspects Genetic diversity Genetic Variation Genome, Bacterial Genomes Genotype Genotypes Health aspects Human Genetics Humans Mass Vaccination Metagenomics Methods Models, Genetic Multigene Family Mutation Phylogeny Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines Pneumonia Population genetics Prevalence Prevention Software Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - immunology United States - epidemiology Vaccines |
| title | Population genomics of post-vaccine changes in pneumococcal epidemiology |
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