Arsenic-Mediated Activation of the Nrf2-Keap1 Antioxidant Pathway

ABSTRACT Arsenic is present in the environment and has become a worldwide health concern due to its toxicity and carcinogenicity. However, the specific mechanism(s) by which arsenic elicits its toxic effects has yet to be fully elucidated. The transcription factor nuclear factor (erythroid‐derived 2...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2013-02, Vol.27 (2), p.99-105
Hauptverfasser:	Lau, Alexandria, Whitman, Samantha A., Jaramillo, Melba C., Zhang, Donna D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Arsenic Arsenic - toxicity Arsenic Poisoning - metabolism Arsenic Poisoning - therapy Autophagy Brassica Chemoprevention Humans Intracellular Signaling Peptides and Proteins - metabolism Keap1 Kelch-Like ECH-Associated Protein 1 NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative stress p62 Signal Transduction - drug effects
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