Nonhematopoietic Cells are the Primary Source of Bone Marrow-Derived Lung Epithelial Cells
Previous studies have demonstrated that bone marrow (BM)‐derived cells differentiate into nonhematopoietic cells of multiple tissues. To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in...
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| Veröffentlicht in: | Stem cells (Dayton, Ohio) Ohio), 2012-03, Vol.30 (3), p.491-499 |
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| creator | Kassmer, Susannah H. Bruscia, Emanuela M. Zhang, Ping-Xia Krause, Diane S. |
| description | Previous studies have demonstrated that bone marrow (BM)‐derived cells differentiate into nonhematopoietic cells of multiple tissues. To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in the BM are the primary source of marrow‐derived lung epithelial cells, either wild‐type hematopoietic or nonhematopoietic BM cells were transplanted into irradiated surfactant‐protein‐C (SPC)‐null mice. Donor‐derived, SPC‐positive type 2 pneumocytes were predominantly detected in the lungs of mice receiving purified nonhematopoietic cells and were absent from mice receiving purified hematopoietic stem and progenitor cells. We conclude that cells contained in the nonhematopoietic fraction of the BM are the primary source of marrow‐derived lung epithelial cells. These nonhematopoietic cells may represent a primitive stem cell population residing in adult BM. STEM CELLS 2012;30:491–499 |
| doi_str_mv | 10.1002/stem.1003 |
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To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in the BM are the primary source of marrow‐derived lung epithelial cells, either wild‐type hematopoietic or nonhematopoietic BM cells were transplanted into irradiated surfactant‐protein‐C (SPC)‐null mice. Donor‐derived, SPC‐positive type 2 pneumocytes were predominantly detected in the lungs of mice receiving purified nonhematopoietic cells and were absent from mice receiving purified hematopoietic stem and progenitor cells. We conclude that cells contained in the nonhematopoietic fraction of the BM are the primary source of marrow‐derived lung epithelial cells. These nonhematopoietic cells may represent a primitive stem cell population residing in adult BM. STEM CELLS 2012;30:491–499</description><identifier>ISSN: 1066-5099</identifier><identifier>EISSN: 1549-4918</identifier><identifier>DOI: 10.1002/stem.1003</identifier><identifier>PMID: 22162244</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Bacterial Proteins - biosynthesis ; Bone marrow ; Bone Marrow Cells - metabolism ; Bone Marrow Cells - physiology ; Bone Marrow Transplantation ; Cell differentiation ; Cell Separation ; Epithelial cells ; Epithelial Cells - metabolism ; Gene Expression ; Luminescent Proteins - biosynthesis ; Lung - cytology ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Confocal ; Pulmonary Surfactant-Associated Protein C - genetics ; Pulmonary Surfactant-Associated Protein C - metabolism ; Recombinant Proteins - biosynthesis ; Single-Cell Analysis ; Stem cells</subject><ispartof>Stem cells (Dayton, Ohio), 2012-03, Vol.30 (3), p.491-499</ispartof><rights>Copyright © 2011 AlphaMed Press</rights><rights>Copyright © 2011 AlphaMed Press.</rights><rights>AlphaMed Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5463-e729bebe40e6ae3f6ed61ee94911744f545f6c0bb0a17991a327ae55295a75193</citedby><cites>FETCH-LOGICAL-c5463-e729bebe40e6ae3f6ed61ee94911744f545f6c0bb0a17991a327ae55295a75193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22162244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kassmer, Susannah H.</creatorcontrib><creatorcontrib>Bruscia, Emanuela M.</creatorcontrib><creatorcontrib>Zhang, Ping-Xia</creatorcontrib><creatorcontrib>Krause, Diane S.</creatorcontrib><title>Nonhematopoietic Cells are the Primary Source of Bone Marrow-Derived Lung Epithelial Cells</title><title>Stem cells (Dayton, Ohio)</title><addtitle>STEM CELLS</addtitle><description>Previous studies have demonstrated that bone marrow (BM)‐derived cells differentiate into nonhematopoietic cells of multiple tissues. To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in the BM are the primary source of marrow‐derived lung epithelial cells, either wild‐type hematopoietic or nonhematopoietic BM cells were transplanted into irradiated surfactant‐protein‐C (SPC)‐null mice. Donor‐derived, SPC‐positive type 2 pneumocytes were predominantly detected in the lungs of mice receiving purified nonhematopoietic cells and were absent from mice receiving purified hematopoietic stem and progenitor cells. We conclude that cells contained in the nonhematopoietic fraction of the BM are the primary source of marrow‐derived lung epithelial cells. These nonhematopoietic cells may represent a primitive stem cell population residing in adult BM. STEM CELLS 2012;30:491–499</description><subject>Animals</subject><subject>Bacterial Proteins - biosynthesis</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Bone Marrow Cells - physiology</subject><subject>Bone Marrow Transplantation</subject><subject>Cell differentiation</subject><subject>Cell Separation</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - metabolism</subject><subject>Gene Expression</subject><subject>Luminescent Proteins - biosynthesis</subject><subject>Lung - cytology</subject><subject>Mice</subject><subject>Mice, 129 Strain</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Microscopy, Confocal</subject><subject>Pulmonary Surfactant-Associated Protein C - genetics</subject><subject>Pulmonary Surfactant-Associated Protein C - metabolism</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Single-Cell Analysis</subject><subject>Stem cells</subject><issn>1066-5099</issn><issn>1549-4918</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS0EoqVw4AsgSxwQh1D_9_qCBMtSENtSsUVIvVhOdtJ1SeLFTlr67XGUZQVInGak-c3TezMIPaXkFSWEHace2rHj99AhlcIUwtDZ_dwTpQpJjDlAj1K6JoQKOZs9RAeMUcWYEIfo8ix0G2hdH7bBQ-8rPIemSdhFwP0G8Hn0rYt3eBWGWAEONX4bOsCnLsZwW7yD6G9gjZdDd4UXW583Gu-aSeMxelC7JsGTXT1CX98vLuYfiuXnk4_zN8uikkLxAjQzJZQgCCgHvFawVhTA5AxUC1FLIWtVkbIkjmpjqONMO5CSGem0pIYfodeT7nYoW1hX0PXRNXY7ObfBefv3pPMbexVuLNdMspnMAi92AjH8GCD1tvWpyhFcB2FI1jCqmSBkJJ__Q17nu3Q5naWUSqbzhXmmXk5UFUNKEeq9F0rs-DA7PmzsRvbZn-b35O8PZeB4Am59A3f_V7Kri8XpTrKYNnwe_txvuPjdKs21tN_OTqw5X8nLT-KLXfFf3YavfA</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Kassmer, Susannah H.</creator><creator>Bruscia, Emanuela M.</creator><creator>Zhang, Ping-Xia</creator><creator>Krause, Diane S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201203</creationdate><title>Nonhematopoietic Cells are the Primary Source of Bone Marrow-Derived Lung Epithelial Cells</title><author>Kassmer, Susannah H. ; Bruscia, Emanuela M. ; Zhang, Ping-Xia ; Krause, Diane S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5463-e729bebe40e6ae3f6ed61ee94911744f545f6c0bb0a17991a327ae55295a75193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bacterial Proteins - biosynthesis</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Bone Marrow Cells - physiology</topic><topic>Bone Marrow Transplantation</topic><topic>Cell differentiation</topic><topic>Cell Separation</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - metabolism</topic><topic>Gene Expression</topic><topic>Luminescent Proteins - biosynthesis</topic><topic>Lung - cytology</topic><topic>Mice</topic><topic>Mice, 129 Strain</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Microscopy, Confocal</topic><topic>Pulmonary Surfactant-Associated Protein C - genetics</topic><topic>Pulmonary Surfactant-Associated Protein C - metabolism</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Single-Cell Analysis</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kassmer, Susannah H.</creatorcontrib><creatorcontrib>Bruscia, Emanuela M.</creatorcontrib><creatorcontrib>Zhang, Ping-Xia</creatorcontrib><creatorcontrib>Krause, Diane S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stem cells (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kassmer, Susannah H.</au><au>Bruscia, Emanuela M.</au><au>Zhang, Ping-Xia</au><au>Krause, Diane S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonhematopoietic Cells are the Primary Source of Bone Marrow-Derived Lung Epithelial Cells</atitle><jtitle>Stem cells (Dayton, Ohio)</jtitle><addtitle>STEM CELLS</addtitle><date>2012-03</date><risdate>2012</risdate><volume>30</volume><issue>3</issue><spage>491</spage><epage>499</epage><pages>491-499</pages><issn>1066-5099</issn><eissn>1549-4918</eissn><abstract>Previous studies have demonstrated that bone marrow (BM)‐derived cells differentiate into nonhematopoietic cells of multiple tissues. To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in the BM are the primary source of marrow‐derived lung epithelial cells, either wild‐type hematopoietic or nonhematopoietic BM cells were transplanted into irradiated surfactant‐protein‐C (SPC)‐null mice. Donor‐derived, SPC‐positive type 2 pneumocytes were predominantly detected in the lungs of mice receiving purified nonhematopoietic cells and were absent from mice receiving purified hematopoietic stem and progenitor cells. We conclude that cells contained in the nonhematopoietic fraction of the BM are the primary source of marrow‐derived lung epithelial cells. These nonhematopoietic cells may represent a primitive stem cell population residing in adult BM. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Bacterial Proteins - biosynthesis Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - physiology Bone Marrow Transplantation Cell differentiation Cell Separation Epithelial cells Epithelial Cells - metabolism Gene Expression Luminescent Proteins - biosynthesis Lung - cytology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal Pulmonary Surfactant-Associated Protein C - genetics Pulmonary Surfactant-Associated Protein C - metabolism Recombinant Proteins - biosynthesis Single-Cell Analysis Stem cells |
| title | Nonhematopoietic Cells are the Primary Source of Bone Marrow-Derived Lung Epithelial Cells |
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