Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness
Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 1...
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| Veröffentlicht in: | The European respiratory journal 2009-06, Vol.33 (6), p.1287-1294 |
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| creator | Sharma, S Murphy, A. J Soto-Quiros, M. E Avila, L Klanderman, B. J Sylvia, J. S Celedon, J. C Raby, B. A Weiss, S. T |
| description | Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica. Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV(1)/FVC decline over approximately 4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness. |
| doi_str_mv | 10.1183/09031936.00113008 |
| format | Article |
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J ; Soto-Quiros, M. E ; Avila, L ; Klanderman, B. J ; Sylvia, J. S ; Celedon, J. C ; Raby, B. A ; Weiss, S. T</creator><creatorcontrib>Sharma, S ; Murphy, A. J ; Soto-Quiros, M. E ; Avila, L ; Klanderman, B. J ; Sylvia, J. S ; Celedon, J. C ; Raby, B. A ; Weiss, S. T</creatorcontrib><description>Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica. Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV(1)/FVC decline over approximately 4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00113008</identifier><identifier>PMID: 19196819</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Adolescent ; Adrenal Cortex Hormones - administration & dosage ; Adrenal Cortex Hormones - therapeutic use ; Anti-Asthmatic Agents - administration & dosage ; Anti-Asthmatic Agents - therapeutic use ; Asthma - drug therapy ; Asthma - genetics ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Provocation Tests ; Child ; Chronic obstructive pulmonary disease, asthma ; Costa Rica ; Double-Blind Method ; European Continental Ancestry Group - genetics ; Female ; Forced Expiratory Volume ; Genotype ; Haplotypes ; Humans ; Male ; Medical sciences ; Nedocromil - administration & dosage ; Nedocromil - therapeutic use ; Phenotype ; Placebos ; Pneumology ; Polymorphism, Single Nucleotide ; Regression Analysis ; Respiratory Function Tests ; Software ; Vascular Endothelial Growth Factor A - genetics ; Vital Capacity</subject><ispartof>The European respiratory journal, 2009-06, Vol.33 (6), p.1287-1294</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright©ERS Journals Ltd 2009 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-63c99cf2fc249daed1d646a7e16f8a6fac0508d0dab93a8ab68ad77ba1abe7843</citedby><cites>FETCH-LOGICAL-c458t-63c99cf2fc249daed1d646a7e16f8a6fac0508d0dab93a8ab68ad77ba1abe7843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21501167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19196819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, S</creatorcontrib><creatorcontrib>Murphy, A. J</creatorcontrib><creatorcontrib>Soto-Quiros, M. E</creatorcontrib><creatorcontrib>Avila, L</creatorcontrib><creatorcontrib>Klanderman, B. J</creatorcontrib><creatorcontrib>Sylvia, J. S</creatorcontrib><creatorcontrib>Celedon, J. C</creatorcontrib><creatorcontrib>Raby, B. A</creatorcontrib><creatorcontrib>Weiss, S. T</creatorcontrib><title>Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica. Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV(1)/FVC decline over approximately 4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness.</description><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Anti-Asthmatic Agents - administration & dosage</subject><subject>Anti-Asthmatic Agents - therapeutic use</subject><subject>Asthma - drug therapy</subject><subject>Asthma - genetics</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Provocation Tests</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Costa Rica</subject><subject>Double-Blind Method</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nedocromil - administration & dosage</subject><subject>Nedocromil - therapeutic use</subject><subject>Phenotype</subject><subject>Placebos</subject><subject>Pneumology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Regression Analysis</subject><subject>Respiratory Function Tests</subject><subject>Software</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vital Capacity</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFv1DAUhC0EotvCD-CCcqEnUvzirGNfkKqqLUiVuABX8-I4G1eOHeykq_33eNvtAic_ab4ZjzSEvAN6ASDYJyopA8n4BaUAjFLxgqyASVnmm70kq71e7oETcprSfaZ4zeA1OQEJkguQK_LrMqWgLc42-CL0xc_r25tiCm43hjgNNo2p2Np5KPRgXTeE0BWY5mHEj4Vb_KboF68freizYuMWd0U0aQo-2QfjTUpvyKseXTJvD-8Z-XFz_f3qS3n37fbr1eVdqeu1mEvOtJS6r3pd1bJD00HHa46NAd4L5D1quqaiox22kqHAlgvsmqZFwNY0omZn5PNT7rS0o-m08XNEp6ZoR4w7FdCq_xVvB7UJD4o11bpqRA44PwTE8HsxaVajTdo4h96EJSneMADKaQbhCdQxpBRNf_wEqNrvop53Uc-7ZM_7f9v9dRyGyMCHA4BJo-sjem3TkatgnaNyhWPLwW6GrY1GpRGdy7GgTLxnTHEFlWjYH59kpek</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Sharma, S</creator><creator>Murphy, A. 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T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-63c99cf2fc249daed1d646a7e16f8a6fac0508d0dab93a8ab68ad77ba1abe7843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Anti-Asthmatic Agents - administration & dosage</topic><topic>Anti-Asthmatic Agents - therapeutic use</topic><topic>Asthma - drug therapy</topic><topic>Asthma - genetics</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Provocation Tests</topic><topic>Child</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Costa Rica</topic><topic>Double-Blind Method</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nedocromil - administration & dosage</topic><topic>Nedocromil - therapeutic use</topic><topic>Phenotype</topic><topic>Placebos</topic><topic>Pneumology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Regression Analysis</topic><topic>Respiratory Function Tests</topic><topic>Software</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, S</creatorcontrib><creatorcontrib>Murphy, A. J</creatorcontrib><creatorcontrib>Soto-Quiros, M. E</creatorcontrib><creatorcontrib>Avila, L</creatorcontrib><creatorcontrib>Klanderman, B. J</creatorcontrib><creatorcontrib>Sylvia, J. S</creatorcontrib><creatorcontrib>Celedon, J. C</creatorcontrib><creatorcontrib>Raby, B. A</creatorcontrib><creatorcontrib>Weiss, S. T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, S</au><au>Murphy, A. J</au><au>Soto-Quiros, M. E</au><au>Avila, L</au><au>Klanderman, B. J</au><au>Sylvia, J. S</au><au>Celedon, J. C</au><au>Raby, B. A</au><au>Weiss, S. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>33</volume><issue>6</issue><spage>1287</spage><epage>1294</epage><pages>1287-1294</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica. Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV(1)/FVC decline over approximately 4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness.</abstract><cop>Leeds</cop><pub>Eur Respiratory Soc</pub><pmid>19196819</pmid><doi>10.1183/09031936.00113008</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - therapeutic use Asthma - drug therapy Asthma - genetics Asthma - physiopathology Biological and medical sciences Bronchial Provocation Tests Child Chronic obstructive pulmonary disease, asthma Costa Rica Double-Blind Method European Continental Ancestry Group - genetics Female Forced Expiratory Volume Genotype Haplotypes Humans Male Medical sciences Nedocromil - administration & dosage Nedocromil - therapeutic use Phenotype Placebos Pneumology Polymorphism, Single Nucleotide Regression Analysis Respiratory Function Tests Software Vascular Endothelial Growth Factor A - genetics Vital Capacity |
| title | Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness |
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