A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

Werner syndrome (WS) is a premature aging disorder where the affected individuals appear much older than their chronological age. The single gene that is defective in WS encodes a protein (WRN) that has ATPase, helicase and 3'-->5' exonuclease activities. Our laboratory has recently unc...

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Veröffentlicht in:	Nucleic acids research 2001-05, Vol.29 (9), p.1926-1934
Hauptverfasser:	Orren, D K, Machwe, A, Karmakar, P, Piotrowski, J, Cooper, M P, Bohr, V A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemistry Antigens, Nuclear Cell Line Cell Nucleus - chemistry DNA - chemistry DNA - metabolism DNA Damage DNA Helicases - analysis DNA Helicases - metabolism DNA Helicases - physiology DNA-Binding Proteins - analysis DNA-Binding Proteins - metabolism DNA-Binding Proteins - pharmacology DNA-Binding Proteins - physiology Exodeoxyribonucleases Exonucleases - analysis Exonucleases - metabolism Exonucleases - physiology Guanine - analogs & derivatives Guanine - chemistry HeLa Cells Humans Ku antigen Ku Autoantigen Nuclear Proteins - analysis Nuclear Proteins - metabolism Nuclear Proteins - physiology RecQ Helicases Replication Protein A V(D)J recombination Werner exonuclease Werner Syndrome Helicase
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