The PIM-2 Kinase Is an Essential Component of the Ultraviolet Damage Response That Acts Upstream to E2F-1 and ATM

The oncogenic nature ascribed to the PIM-2 kinase relies mostly on phosphorylation of substrates that act as pro-survival/anti-apoptotic factors. Nevertheless, pro-survival effects can also result from activating DNA repair mechanisms following damage. In this study, we addressed the possibility tha...

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Veröffentlicht in:	The Journal of biological chemistry 2013-07, Vol.288 (30), p.21770-21783
Hauptverfasser:	Zirkin, Shahar, Davidovich, Ateret, Don, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Ataxia Telangiectasia Mutated Proteins ATM Base Excision Repair Blotting, Western Cancer Biology Cell Biology Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Signaling DNA Damage DNA Damage Response DNA Repair DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism E2F-1 E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism Enzyme Activation Gene Expression Regulation, Neoplastic - drug effects Histones - metabolism Humans Immunohistochemistry Morpholines - pharmacology PIM-2 Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Thioxanthenes - pharmacology Time Factors Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - metabolism Ultraviolet Rays
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