α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

Early α-synuclein (α-Syn)-induced alterations are neurite pathologies resulting in Lewy neurites. α-Syn oligomers are a toxic species in synucleinopathies and are suspected to cause neuritic pathology. To investigate how α-Syn oligomers may be linked to aberrant neurite pathology, we modeled differe...

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Veröffentlicht in:	The Journal of biological chemistry 2013-07, Vol.288 (30), p.21742-21754
Hauptverfasser:	Prots, Iryna, Veber, Vanesa, Brey, Stefanie, Campioni, Silvia, Buder, Katrin, Riek, Roland, Böhm, Konrad J., Winner, Beate
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - metabolism Cell Line Cell Survival - genetics Cytoskeletal Proteins - metabolism Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Electrophoresis, Polyacrylamide Gel Humans Kinesin Kinesin - metabolism Microscopy, Fluorescence Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Mutation Neurite Neurites - metabolism Neurites - pathology Neurobiology Neurodegeneration Oligomers Protein Binding Protein Multimerization tau Proteins - metabolism Transport Tubulin - metabolism
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