The Small GTPase RALA Controls c-Jun N-terminal Kinase-mediated FOXO Activation by Regulation of a JIP1 Scaffold Complex

FOXO (forkhead box O) transcription factors are tumor suppressors and increase the life spans of model organisms. Cellular stress, in particular oxidative stress caused by an increase in levels of reactive oxygen species (ROS), activates FOXOs through JNK-mediated phosphorylation. Importantly, JNK r...

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Veröffentlicht in:	The Journal of biological chemistry 2013-07, Vol.288 (30), p.21729-21741
Hauptverfasser:	van den Berg, Maaike C.W., van Gogh, Inkie J.A., Smits, Alida M.M., van Triest, Miranda, Dansen, Tobias B., Visscher, Marieke, Polderman, Paulien E., Vliem, Marjolein J., Rehmann, Holger, Burgering, Boudewijn M.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Blotting, Western C. elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Cycle Proteins Cell Nucleus - metabolism Enzyme Activation Forkhead Transcription Factors HEK293 Cells Humans MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinases (MAPKs) Mice Mitogen-Activated Protein Kinase 8 - genetics Mitogen-Activated Protein Kinase 8 - metabolism Mutation NIH 3T3 Cells ral GTP-Binding Proteins - genetics ral GTP-Binding Proteins - metabolism Reactive Oxygen Species (ROS) Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Scaffold Proteins Signal Transduction Small GTPases Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism
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