Reduction of microglial activity in a model of multiple sclerosis by dipyridamole

Despite extensive and persistent activation of microglia in multiple sclerosis (MS), microglia inhibitors have not yet been identified for treatment of the disorder. We sought to identify medications already in clinical use that could inhibit the activation of microglia. On the basis of the reported...

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Veröffentlicht in:	Journal of neuroinflammation 2013-07, Vol.10 (1), p.89-89, Article 855
Hauptverfasser:	Sloka, Scott, Metz, Luanne M, Hader, Walter, Starreveld, Yves, Yong, V Wee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Analysis Animals Brain research Cell Survival - drug effects Cells, Cultured Culture Media, Conditioned Cytokines - biosynthesis Dipyridamole Dipyridamole - therapeutic use Dosage and administration Encephalomyelitis, Autoimmune, Experimental - drug therapy Experiments Female Fluorescent Antibody Technique Humans Image Processing, Computer-Assisted In Vitro Techniques Inflammation Lipopolysaccharides - pharmacology Macrophages - drug effects Medical research Mice Mice, Inbred C57BL Microglia - drug effects Microglia - pathology Microglia - ultrastructure Multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis - pathology Neurology Phagocytosis - drug effects Physiological aspects Platelet Aggregation Inhibitors - therapeutic use Rodents Software Statistical analysis
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