Gut microbial colonisation in premature neonates predicts neonatal sepsis

Background Neonatal sepsis due to intestinal bacterial translocation is a major cause of morbidity and mortality. Understanding microbial colonisation of the gut in prematurity may predict risk of sepsis to guide future strategies to manipulate the microbiome. Methods Prospective longitudinal study...

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Veröffentlicht in:	Archives of disease in childhood. Fetal and neonatal edition 2012-11, Vol.97 (6), p.F456-F462
Hauptverfasser:	Madan, Juliette C, Salari, Richard Cowper, Saxena, Deepti, Davidson, Lisa, O'Toole, George A, Moore, Jason H, Sogin, Mitchell L, Foster, James A, Edwards, William H, Palumbo, Paul, Hibberd, Patricia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Bacterial Translocation Base Sequence Birth weight Breastfeeding & lactation Clostridium Colonization Colony Count, Microbial Deoxyribonucleic acid DNA Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Gastrointestinal Tract - microbiology Human subjects Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - drug therapy Infant, Premature, Diseases - microbiology Infant, Very Low Birth Weight Infants Intensive care Klebsiella Laboratories Lactobacillus Lifesaving Longitudinal Studies Meconium - microbiology Molecular Sequence Data Mortality Neonates Pathogens Premature birth Risk Factors RNA, Messenger Sepsis Sepsis - microbiology Staphylococcus Staphylococcus - genetics Staphylococcus - isolation & purification Studies Translocation
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