In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs are the current trea...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-7 |
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| creator | Colares, Aracélio Viana Almeida-Souza, Fernando Taniwaki, Noemi Nosomi Souza, Celeste da Silva Freitas Costa, José Galberto Martins da Calabrese, Kátia da Silva Abreu-Silva, Ana Lúcia |
| description | The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound α-bisabolol against Leishmania amazonensis. The essential oil and α-bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 μg/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 μg/mL, resp.). Neither product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or α-bisabolol at 30 μg/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions. The results give evidence that both VAEO and α-bisabolol have potential as new therapeutic agents against leishmaniasis. |
| doi_str_mv | 10.1155/2013/727042 |
| format | Article |
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Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound α-bisabolol against Leishmania amazonensis. The essential oil and α-bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 μg/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 μg/mL, resp.). Neither product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or α-bisabolol at 30 μg/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions. The results give evidence that both VAEO and α-bisabolol have potential as new therapeutic agents against leishmaniasis.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/727042</identifier><identifier>PMID: 23935675</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Amastigotes ; Antimicrobial agents ; Asteraceae ; Chemical agents ; Chemical compounds ; Chemotherapy ; Cytotoxicity ; Essential oils ; Folk medicine ; Fungi ; Infectious diseases ; Leishmania amazonensis ; Leishmaniasis ; Macrophages ; Natural products ; Oils & fats ; Parasites ; Parasitic diseases ; Penicillin ; Promastigotes ; Protozoa ; Side effects ; Vector-borne diseases ; Wound healing</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-7</ispartof><rights>Copyright © 2013 Aracélio Viana Colares et al.</rights><rights>Copyright © 2013 Aracélio Viana Colares et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Aracélio Viana Colares et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-e57010d9bfafb9cb07816d16affc21214a2919386e59e2c5b255210461bffa793</citedby><cites>FETCH-LOGICAL-c462t-e57010d9bfafb9cb07816d16affc21214a2919386e59e2c5b255210461bffa793</cites><orcidid>0000-0003-2167-3725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723306/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723306/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23935675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Albuquerque, Ulysses Paulino</contributor><creatorcontrib>Colares, Aracélio Viana</creatorcontrib><creatorcontrib>Almeida-Souza, Fernando</creatorcontrib><creatorcontrib>Taniwaki, Noemi Nosomi</creatorcontrib><creatorcontrib>Souza, Celeste da Silva Freitas</creatorcontrib><creatorcontrib>Costa, José Galberto Martins da</creatorcontrib><creatorcontrib>Calabrese, Kátia da Silva</creatorcontrib><creatorcontrib>Abreu-Silva, Ana Lúcia</creatorcontrib><title>In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound α-bisabolol against Leishmania amazonensis. The essential oil and α-bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 μg/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 μg/mL, resp.). Neither product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or α-bisabolol at 30 μg/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions. The results give evidence that both VAEO and α-bisabolol have potential as new therapeutic agents against leishmaniasis.</description><subject>Amastigotes</subject><subject>Antimicrobial agents</subject><subject>Asteraceae</subject><subject>Chemical agents</subject><subject>Chemical compounds</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Essential oils</subject><subject>Folk medicine</subject><subject>Fungi</subject><subject>Infectious diseases</subject><subject>Leishmania amazonensis</subject><subject>Leishmaniasis</subject><subject>Macrophages</subject><subject>Natural products</subject><subject>Oils & fats</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Penicillin</subject><subject>Promastigotes</subject><subject>Protozoa</subject><subject>Side effects</subject><subject>Vector-borne diseases</subject><subject>Wound 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Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound α-bisabolol against Leishmania amazonensis. The essential oil and α-bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 μg/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 μg/mL, resp.). Neither product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or α-bisabolol at 30 μg/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions. 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| subjects | Amastigotes Antimicrobial agents Asteraceae Chemical agents Chemical compounds Chemotherapy Cytotoxicity Essential oils Folk medicine Fungi Infectious diseases Leishmania amazonensis Leishmaniasis Macrophages Natural products Oils & fats Parasites Parasitic diseases Penicillin Promastigotes Protozoa Side effects Vector-borne diseases Wound healing |
| title | In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker |
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