Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

The N-acylethanolamine acid amidase inhibitor ARN077 exerts profound antinociceptive effects in animal pain models by enhancing endogenous lipid signaling at peroxisome proliferator-activated receptor-α. N-acylethanolamine acid amidase may be a new target for analgesic drugs. Fatty acid ethanolamide...

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Veröffentlicht in:	Pain (Amsterdam) 2013-03, Vol.154 (3), p.350-360
Hauptverfasser:	Sasso, Oscar, Moreno-Sanz, Guillermo, Martucci, Cataldo, Realini, Natalia, Dionisi, Mauro, Mengatto, Luisa, Duranti, Andrea, Tarozzo, Glauco, Tarzia, Giorgio, Mor, Marco, Bertorelli, Rosalia, Reggiani, Angelo, Piomelli, Daniele
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Amidohydrolases - antagonists & inhibitors Amidohydrolases - genetics Amidohydrolases - physiology Analgesics - administration & dosage Analgesics - pharmacology Analgesics - therapeutic use Animals Biological and medical sciences Burns - drug therapy Burns - etiology Carbamates - administration & dosage Carbamates - pharmacology Carbamates - therapeutic use Carrageenan - toxicity Chronic constriction injury Dose-Response Relationship, Drug Drug Evaluation, Preclinical Endocannabinoids - physiology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Ethanolamines Ethers, Cyclic - administration & dosage Ethers, Cyclic - pharmacology Ethers, Cyclic - therapeutic use Fundamental and applied biological sciences. Psychology HEK293 Cells Humans Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - physiopathology Lysosomes - enzymology Male Mice Mice, Inbred C57BL Mice, Knockout Oleic Acids - physiology Oleoylethanolamide Pain Perception - drug effects Pain Perception - physiology Palmitic Acids Palmitoylethanolamide Peroxisome proliferator-activated receptor-α PPAR alpha - agonists PPAR alpha - deficiency PPAR alpha - physiology Radiation Injuries - drug therapy Radiation Injuries - etiology Rats Recombinant Fusion Proteins - physiology Sciatic Nerve - injuries Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Tetradecanoylphorbol Acetate - toxicity Ultraviolet Rays - adverse effects UVB-induced erythema Vertebrates: nervous system and sense organs λ-Carrageenan
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