Joint Involvement in Primary Sjögren’s Syndrome: An Ultrasound “Target Area Approach to Arthritis”
To characterize the ultrasound (US) pattern of joint involvement in primary Sjögren’s syndrome (pSS). Methods. Seventeen patients with pSS, 18 with secondary Sjögren’s syndrome (sSS), and 17 healthy controls underwent US examinations of various articular regions. Synovitis (synovial hypertrophy/join...
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| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-9 |
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| creator | Pineda, C. Gutierrez, Marwin Castillo-Martinez, Diana Hernández-Díaz, Cristina Solano, Carla Rodriguez-Henriquez, Pedro Vargas, Angelica Hofmann, Fritz Amezcua-Guerra, Luis M. Ventura-Ríos, Lucio |
| description | To characterize the ultrasound (US) pattern of joint involvement in primary Sjögren’s syndrome (pSS). Methods. Seventeen patients with pSS, 18 with secondary Sjögren’s syndrome (sSS), and 17 healthy controls underwent US examinations of various articular regions. Synovitis (synovial hypertrophy/joint effusion), power Doppler (PD) signals, and erosions were assessed. Results. In patients with pSS, synovitis was found in the metacarpophalangeal joints (MCP, 76%), wrists (76%), and knees (76%), while the proximal interphalangeal joints, elbows, and ankles were mostly unscathed. Intra-articular PD signals were occasionally detected in wrists (12%), elbows (6%), and knees (6%). Erosions were evident in the wrists of three (18%) patients with pSS, one of these also having anti-cyclic citrullinated peptide (anti-CCP) antibodies. While US synovitis does not discriminate between sSS and pSS, demonstration of bone erosions in the 2nd MCP joints showed 28.8% sensitivity and 100% specificity for diagnosing sSS; in comparison, these figures were 72.2 and 94.1% for circulating anti-CCP antibodies. Conclusions. In pSS, the pattern of joint involvement by US is polyarticular, bilateral, and symmetrical. Synovitis is the US sign most commonly found in patients with pSS, especially in MCP joints, wrists, and knees, and bone erosions also may occur. |
| doi_str_mv | 10.1155/2013/640265 |
| format | Article |
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Methods. Seventeen patients with pSS, 18 with secondary Sjögren’s syndrome (sSS), and 17 healthy controls underwent US examinations of various articular regions. Synovitis (synovial hypertrophy/joint effusion), power Doppler (PD) signals, and erosions were assessed. Results. In patients with pSS, synovitis was found in the metacarpophalangeal joints (MCP, 76%), wrists (76%), and knees (76%), while the proximal interphalangeal joints, elbows, and ankles were mostly unscathed. Intra-articular PD signals were occasionally detected in wrists (12%), elbows (6%), and knees (6%). Erosions were evident in the wrists of three (18%) patients with pSS, one of these also having anti-cyclic citrullinated peptide (anti-CCP) antibodies. While US synovitis does not discriminate between sSS and pSS, demonstration of bone erosions in the 2nd MCP joints showed 28.8% sensitivity and 100% specificity for diagnosing sSS; in comparison, these figures were 72.2 and 94.1% for circulating anti-CCP antibodies. Conclusions. In pSS, the pattern of joint involvement by US is polyarticular, bilateral, and symmetrical. Synovitis is the US sign most commonly found in patients with pSS, especially in MCP joints, wrists, and knees, and bone erosions also may occur.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/640265</identifier><identifier>PMID: 23936829</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies ; Arthritis ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - diagnostic imaging ; Arthritis, Rheumatoid - pathology ; Diagnosis ; Female ; Humans ; Knee - diagnostic imaging ; Knee - pathology ; Lupus ; Male ; Metacarpophalangeal Joint - diagnostic imaging ; Metacarpophalangeal Joint - pathology ; Middle Aged ; Rheumatoid arthritis ; Rheumatology ; Sjogren's syndrome ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - diagnostic imaging ; Sjogren's Syndrome - pathology ; Studies ; Synovitis - complications ; Synovitis - diagnostic imaging ; Synovitis - pathology ; Ultrasonic imaging ; Ultrasonography ; Ultrasound imaging ; Wrist - diagnostic imaging ; Wrist - pathology</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-9</ispartof><rights>Copyright © 2013 Luis M. Amezcua-Guerra et al.</rights><rights>COPYRIGHT 2013 John Wiley & Sons, Inc.</rights><rights>Copyright © 2013 Luis M. Amezcua-Guerra et al. Luis M. Amezcua-Guerra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Luis M. Amezcua-Guerra et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-ff19ee143edfbf64dd2744cbdac68c5a128c992e2f08de6ff07d69f6025a49ad3</citedby><cites>FETCH-LOGICAL-c528t-ff19ee143edfbf64dd2744cbdac68c5a128c992e2f08de6ff07d69f6025a49ad3</cites><orcidid>0000-0002-8048-1689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722787/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722787/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23936829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mahler, Michael</contributor><creatorcontrib>Pineda, C.</creatorcontrib><creatorcontrib>Gutierrez, Marwin</creatorcontrib><creatorcontrib>Castillo-Martinez, Diana</creatorcontrib><creatorcontrib>Hernández-Díaz, Cristina</creatorcontrib><creatorcontrib>Solano, Carla</creatorcontrib><creatorcontrib>Rodriguez-Henriquez, Pedro</creatorcontrib><creatorcontrib>Vargas, Angelica</creatorcontrib><creatorcontrib>Hofmann, Fritz</creatorcontrib><creatorcontrib>Amezcua-Guerra, Luis M.</creatorcontrib><creatorcontrib>Ventura-Ríos, Lucio</creatorcontrib><title>Joint Involvement in Primary Sjögren’s Syndrome: An Ultrasound “Target Area Approach to Arthritis”</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>To characterize the ultrasound (US) pattern of joint involvement in primary Sjögren’s syndrome (pSS). Methods. Seventeen patients with pSS, 18 with secondary Sjögren’s syndrome (sSS), and 17 healthy controls underwent US examinations of various articular regions. Synovitis (synovial hypertrophy/joint effusion), power Doppler (PD) signals, and erosions were assessed. Results. In patients with pSS, synovitis was found in the metacarpophalangeal joints (MCP, 76%), wrists (76%), and knees (76%), while the proximal interphalangeal joints, elbows, and ankles were mostly unscathed. Intra-articular PD signals were occasionally detected in wrists (12%), elbows (6%), and knees (6%). Erosions were evident in the wrists of three (18%) patients with pSS, one of these also having anti-cyclic citrullinated peptide (anti-CCP) antibodies. While US synovitis does not discriminate between sSS and pSS, demonstration of bone erosions in the 2nd MCP joints showed 28.8% sensitivity and 100% specificity for diagnosing sSS; in comparison, these figures were 72.2 and 94.1% for circulating anti-CCP antibodies. Conclusions. In pSS, the pattern of joint involvement by US is polyarticular, bilateral, and symmetrical. Synovitis is the US sign most commonly found in patients with pSS, especially in MCP joints, wrists, and knees, and bone erosions also may occur.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Knee - diagnostic imaging</subject><subject>Knee - pathology</subject><subject>Lupus</subject><subject>Male</subject><subject>Metacarpophalangeal Joint - diagnostic imaging</subject><subject>Metacarpophalangeal Joint - pathology</subject><subject>Middle Aged</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Sjogren's syndrome</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - diagnostic imaging</subject><subject>Sjogren's Syndrome - pathology</subject><subject>Studies</subject><subject>Synovitis - complications</subject><subject>Synovitis - diagnostic imaging</subject><subject>Synovitis - pathology</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound imaging</subject><subject>Wrist - diagnostic imaging</subject><subject>Wrist - pathology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkt1qFDEYhgdRbKk98lwCnoiyNn-TmXhQGIo_lYJC2-OQzc9ulplkTWZWera3IehteAPeyV6JGaau1aPmJB_Jw_vl_fIWxVMEXyNUlicYInLCKMSsfFAcYoLojCGKHu5rQg6K45RWMK8aMcjZ4-IAE05Yjflh4T4G53tw7jeh3ZjO5Np58Dm6TsYbcLn69XMRjd9tvyVweeN1DJ15AxoPrts-yhQGr8Fu-_1KxoXpQRONBM16HYNUS9CHfNAvo-td2m1_PCkeWdkmc3y7HxXX795enX2YXXx6f37WXMxUiet-Zi3ixiBKjLZzy6jWuKJUzbVUrFalRLhWnGODLay1YdbCSjNuGcSlpFxqclScTrrrYd4ZrbKlKFuxniyJIJ3498a7pViEjSAVxlVdZYEXtwIxfBlM6kXnkjJtK70JQxKIUkKqGlX4Hmj-H0Yo4hl9_h-6CkP0eRIjVUOEOSz_UgvZGuG8DfmJahQVDalyW4LxqPVqolQMKUVj9-4QFGMsxBgLMcUi08_uDmTP_glBBl5OwNJ5Lb-6-6mZjBgr78CQVhyS3973zAk</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Pineda, C.</creator><creator>Gutierrez, Marwin</creator><creator>Castillo-Martinez, Diana</creator><creator>Hernández-Díaz, Cristina</creator><creator>Solano, Carla</creator><creator>Rodriguez-Henriquez, Pedro</creator><creator>Vargas, Angelica</creator><creator>Hofmann, Fritz</creator><creator>Amezcua-Guerra, Luis M.</creator><creator>Ventura-Ríos, Lucio</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8048-1689</orcidid></search><sort><creationdate>20130101</creationdate><title>Joint Involvement in Primary Sjögren’s Syndrome: An Ultrasound “Target Area Approach to Arthritis”</title><author>Pineda, C. ; Gutierrez, Marwin ; Castillo-Martinez, Diana ; Hernández-Díaz, Cristina ; Solano, Carla ; Rodriguez-Henriquez, Pedro ; Vargas, Angelica ; Hofmann, Fritz ; Amezcua-Guerra, Luis M. ; Ventura-Ríos, Lucio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-ff19ee143edfbf64dd2744cbdac68c5a128c992e2f08de6ff07d69f6025a49ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Knee - diagnostic imaging</topic><topic>Knee - pathology</topic><topic>Lupus</topic><topic>Male</topic><topic>Metacarpophalangeal Joint - diagnostic imaging</topic><topic>Metacarpophalangeal Joint - pathology</topic><topic>Middle Aged</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Sjogren's syndrome</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - diagnostic imaging</topic><topic>Sjogren's Syndrome - pathology</topic><topic>Studies</topic><topic>Synovitis - complications</topic><topic>Synovitis - diagnostic imaging</topic><topic>Synovitis - pathology</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasound imaging</topic><topic>Wrist - diagnostic imaging</topic><topic>Wrist - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pineda, C.</creatorcontrib><creatorcontrib>Gutierrez, Marwin</creatorcontrib><creatorcontrib>Castillo-Martinez, Diana</creatorcontrib><creatorcontrib>Hernández-Díaz, Cristina</creatorcontrib><creatorcontrib>Solano, Carla</creatorcontrib><creatorcontrib>Rodriguez-Henriquez, Pedro</creatorcontrib><creatorcontrib>Vargas, Angelica</creatorcontrib><creatorcontrib>Hofmann, Fritz</creatorcontrib><creatorcontrib>Amezcua-Guerra, Luis M.</creatorcontrib><creatorcontrib>Ventura-Ríos, Lucio</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pineda, C.</au><au>Gutierrez, Marwin</au><au>Castillo-Martinez, Diana</au><au>Hernández-Díaz, Cristina</au><au>Solano, Carla</au><au>Rodriguez-Henriquez, Pedro</au><au>Vargas, Angelica</au><au>Hofmann, Fritz</au><au>Amezcua-Guerra, Luis M.</au><au>Ventura-Ríos, Lucio</au><au>Mahler, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Joint Involvement in Primary Sjögren’s Syndrome: An Ultrasound “Target Area Approach to Arthritis”</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>To characterize the ultrasound (US) pattern of joint involvement in primary Sjögren’s syndrome (pSS). Methods. Seventeen patients with pSS, 18 with secondary Sjögren’s syndrome (sSS), and 17 healthy controls underwent US examinations of various articular regions. Synovitis (synovial hypertrophy/joint effusion), power Doppler (PD) signals, and erosions were assessed. Results. In patients with pSS, synovitis was found in the metacarpophalangeal joints (MCP, 76%), wrists (76%), and knees (76%), while the proximal interphalangeal joints, elbows, and ankles were mostly unscathed. Intra-articular PD signals were occasionally detected in wrists (12%), elbows (6%), and knees (6%). Erosions were evident in the wrists of three (18%) patients with pSS, one of these also having anti-cyclic citrullinated peptide (anti-CCP) antibodies. While US synovitis does not discriminate between sSS and pSS, demonstration of bone erosions in the 2nd MCP joints showed 28.8% sensitivity and 100% specificity for diagnosing sSS; in comparison, these figures were 72.2 and 94.1% for circulating anti-CCP antibodies. Conclusions. In pSS, the pattern of joint involvement by US is polyarticular, bilateral, and symmetrical. Synovitis is the US sign most commonly found in patients with pSS, especially in MCP joints, wrists, and knees, and bone erosions also may occur.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23936829</pmid><doi>10.1155/2013/640265</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8048-1689</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antibodies Arthritis Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - pathology Diagnosis Female Humans Knee - diagnostic imaging Knee - pathology Lupus Male Metacarpophalangeal Joint - diagnostic imaging Metacarpophalangeal Joint - pathology Middle Aged Rheumatoid arthritis Rheumatology Sjogren's syndrome Sjogren's Syndrome - complications Sjogren's Syndrome - diagnostic imaging Sjogren's Syndrome - pathology Studies Synovitis - complications Synovitis - diagnostic imaging Synovitis - pathology Ultrasonic imaging Ultrasonography Ultrasound imaging Wrist - diagnostic imaging Wrist - pathology |
| title | Joint Involvement in Primary Sjögren’s Syndrome: An Ultrasound “Target Area Approach to Arthritis” |
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