Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress

Licochalcone A (LCA), a licorice chalconoid, is considered to be a bioactive agent with chemopreventive potential. This study investigated the mechanisms involved in LCA-induced apoptosis in human bladder cancer T24 cells. LCA significantly inhibited cells proliferation, increased reactive oxygen sp...

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Veröffentlicht in:	BioMed research international 2013-01, Vol.2013 (2013), p.1-9
Hauptverfasser:	Zheng, Qiusheng, Ma, Xiaoyi, Wang, Penglong, Jiang, Jiangtao, Zhao, Hong, Li, Defang, Yuan, Xuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Apoptosis Apoptosis - drug effects Bladder cancer Cancer therapies Care and treatment Cell culture Cell Line, Tumor Cell Proliferation - drug effects Chalcones - pharmacology Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Glucose metabolism Glycyrrhiza glabra Homeostasis HSP70 Heat-Shock Proteins - metabolism Humans Membrane Proteins - metabolism Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Oxidative stress Oxidative Stress - drug effects Physiological aspects Reactive Oxygen Species - metabolism Signal transduction Signal Transduction - drug effects Stress response Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology
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