Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity
Background Nephron number in humans is determined during fetal life. The objective of this study was to investigate the effects of preterm birth on nephron number using renal volume as a surrogate for nephron number. Methods This observational study was conducted over 12 months in a tertiary perinat...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2013-09, Vol.28 (9), p.1791-1796 |
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| creator | Kandasamy, Yogavijayan Smith, Roger Wright, Ian M. R. Lumbers, Eugenie R. |
| description | Background
Nephron number in humans is determined during fetal life. The objective of this study was to investigate the effects of preterm birth on nephron number using renal volume as a surrogate for nephron number.
Methods
This observational study was conducted over 12 months in a tertiary perinatal center. Preterm babies less than 32 weeks of gestation were recruited and followed until discharge. Term infants were recruited for comparison. The babies underwent renal sonography and renal function measurements at 32 and 38 weeks corrected age. The primary outcome measurement was total kidney volume at 38 weeks and the secondary outcome was estimated glomerular filtration rate (eGFR).
Results
Forty-four preterm infants and 24 term infants were recruited. At 38 weeks corrected age, premature infants had lower total kidney volume than term infants (21.6 ± 5.7 vs. 25.2 ± 5.7 ml;
p
= 0.02) and a significantly lower eGFR (73.6 [IQR 68.1–77.6] vs. 79.3 [IQR 72.5–86.6] ml·min
−1
·1.73 m
−2
;
p
= 0.03). There was a significant correlation between total kidney volume and eGFR in premature and term babies.
Conclusions
Premature infants have smaller kidney volume and likely decreased nephron number and lower estimated glomerulofiltration rate relative to infants born at term. |
| doi_str_mv | 10.1007/s00467-013-2462-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3722455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A344827881</galeid><sourcerecordid>A344827881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c672t-d2710a72491d2ba12787e61a08035af613b253f9e930822eda03b7fcaa4d463a3</originalsourceid><addsrcrecordid>eNp1kl2L1DAUhoMo7jj6A7yRgiDedD35aNN6sbAs6wcszI3C3oVMe9pmaZMxSdX592acdZ2RkVwk5DznTc7LS8hLCucUQL4LAKKUOVCeM1GynD8iCyo4y2ld3T4mC6g5zUHQ2zPyLIQ7AKiKqnxKzhgvCg6iWJDV9c_odT5H9MZi5tHqMeu9-xGHzNhs4zFVpnTstI3hfbYaTe8sbgbvNjoO20zbdkdNOs7exO1z8qTTY8AX9_uSfP1w_eXqU36z-vj56vImb0rJYt4ySUFLJmrasrWmTFYSS6qhAl7orqR8zQre1VhzqBjDVgNfy67RWrSi5JovycVedzOvJ2wbtGmMUW28mbTfKqeNOq5YM6jefVdcMibS9Evy9l7Au28zhqgmExocR23RzUFRQTktWc0goa__Qe_c7JNRvykGtRRS_KV6PaJKhrn0brMTVZdciCqNWNFE5SeoHi2mTyZjO5Ouj_jzE3xaLU6mOdnw5qBhQD3GIbhxjsbZcAzSPdh4F4LH7sE8CmoXL7WPl0rxUrt4KZ56Xh26_tDxJ08JYHsgpJLt0R9Y9V_VX_Id2Ko</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1412097474</pqid></control><display><type>article</type><title>Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Kandasamy, Yogavijayan ; Smith, Roger ; Wright, Ian M. R. ; Lumbers, Eugenie R.</creator><creatorcontrib>Kandasamy, Yogavijayan ; Smith, Roger ; Wright, Ian M. R. ; Lumbers, Eugenie R.</creatorcontrib><description>Background
Nephron number in humans is determined during fetal life. The objective of this study was to investigate the effects of preterm birth on nephron number using renal volume as a surrogate for nephron number.
Methods
This observational study was conducted over 12 months in a tertiary perinatal center. Preterm babies less than 32 weeks of gestation were recruited and followed until discharge. Term infants were recruited for comparison. The babies underwent renal sonography and renal function measurements at 32 and 38 weeks corrected age. The primary outcome measurement was total kidney volume at 38 weeks and the secondary outcome was estimated glomerular filtration rate (eGFR).
Results
Forty-four preterm infants and 24 term infants were recruited. At 38 weeks corrected age, premature infants had lower total kidney volume than term infants (21.6 ± 5.7 vs. 25.2 ± 5.7 ml;
p
= 0.02) and a significantly lower eGFR (73.6 [IQR 68.1–77.6] vs. 79.3 [IQR 72.5–86.6] ml·min
−1
·1.73 m
−2
;
p
= 0.03). There was a significant correlation between total kidney volume and eGFR in premature and term babies.
Conclusions
Premature infants have smaller kidney volume and likely decreased nephron number and lower estimated glomerulofiltration rate relative to infants born at term.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-013-2462-3</identifier><identifier>PMID: 23553045</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anthropometry ; Autopsies ; Birth weight ; Blood pressure ; Blood Pressure - physiology ; Children ; Creatinine - blood ; Cystatin C - blood ; Diseases ; Female ; Gestational Age ; Glomerular Filtration Rate - physiology ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infant, Premature - growth & development ; Infant, Small for Gestational Age ; Infants (Premature) ; Kidney - diagnostic imaging ; Kidney - growth & development ; Kidney - pathology ; Kidney diseases ; Kidney Diseases - congenital ; Kidney Diseases - diagnostic imaging ; Kidney Diseases - pathology ; Kidney tubules ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Neonatal care ; Nephrology ; Nephrons - pathology ; Newborn babies ; Observational studies ; Original ; Original Article ; Pediatrics ; Physiological aspects ; Premature babies ; Premature birth ; Treatment Outcome ; Ultrasonic imaging ; Ultrasonography ; Urology</subject><ispartof>Pediatric nephrology (Berlin, West), 2013-09, Vol.28 (9), p.1791-1796</ispartof><rights>The Author(s) 2013</rights><rights>COPYRIGHT 2013 Springer</rights><rights>IPNA 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c672t-d2710a72491d2ba12787e61a08035af613b253f9e930822eda03b7fcaa4d463a3</citedby><cites>FETCH-LOGICAL-c672t-d2710a72491d2ba12787e61a08035af613b253f9e930822eda03b7fcaa4d463a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-013-2462-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-013-2462-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23553045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kandasamy, Yogavijayan</creatorcontrib><creatorcontrib>Smith, Roger</creatorcontrib><creatorcontrib>Wright, Ian M. R.</creatorcontrib><creatorcontrib>Lumbers, Eugenie R.</creatorcontrib><title>Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
Nephron number in humans is determined during fetal life. The objective of this study was to investigate the effects of preterm birth on nephron number using renal volume as a surrogate for nephron number.
Methods
This observational study was conducted over 12 months in a tertiary perinatal center. Preterm babies less than 32 weeks of gestation were recruited and followed until discharge. Term infants were recruited for comparison. The babies underwent renal sonography and renal function measurements at 32 and 38 weeks corrected age. The primary outcome measurement was total kidney volume at 38 weeks and the secondary outcome was estimated glomerular filtration rate (eGFR).
Results
Forty-four preterm infants and 24 term infants were recruited. At 38 weeks corrected age, premature infants had lower total kidney volume than term infants (21.6 ± 5.7 vs. 25.2 ± 5.7 ml;
p
= 0.02) and a significantly lower eGFR (73.6 [IQR 68.1–77.6] vs. 79.3 [IQR 72.5–86.6] ml·min
−1
·1.73 m
−2
;
p
= 0.03). There was a significant correlation between total kidney volume and eGFR in premature and term babies.
Conclusions
Premature infants have smaller kidney volume and likely decreased nephron number and lower estimated glomerulofiltration rate relative to infants born at term.</description><subject>Anthropometry</subject><subject>Autopsies</subject><subject>Birth weight</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Children</subject><subject>Creatinine - blood</subject><subject>Cystatin C - blood</subject><subject>Diseases</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - growth & development</subject><subject>Infant, Small for Gestational Age</subject><subject>Infants (Premature)</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - growth & development</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - congenital</subject><subject>Kidney Diseases - diagnostic imaging</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney tubules</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Neonatal care</subject><subject>Nephrology</subject><subject>Nephrons - pathology</subject><subject>Newborn babies</subject><subject>Observational studies</subject><subject>Original</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Urology</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kl2L1DAUhoMo7jj6A7yRgiDedD35aNN6sbAs6wcszI3C3oVMe9pmaZMxSdX592acdZ2RkVwk5DznTc7LS8hLCucUQL4LAKKUOVCeM1GynD8iCyo4y2ld3T4mC6g5zUHQ2zPyLIQ7AKiKqnxKzhgvCg6iWJDV9c_odT5H9MZi5tHqMeu9-xGHzNhs4zFVpnTstI3hfbYaTe8sbgbvNjoO20zbdkdNOs7exO1z8qTTY8AX9_uSfP1w_eXqU36z-vj56vImb0rJYt4ySUFLJmrasrWmTFYSS6qhAl7orqR8zQre1VhzqBjDVgNfy67RWrSi5JovycVedzOvJ2wbtGmMUW28mbTfKqeNOq5YM6jefVdcMibS9Evy9l7Au28zhqgmExocR23RzUFRQTktWc0goa__Qe_c7JNRvykGtRRS_KV6PaJKhrn0brMTVZdciCqNWNFE5SeoHi2mTyZjO5Ouj_jzE3xaLU6mOdnw5qBhQD3GIbhxjsbZcAzSPdh4F4LH7sE8CmoXL7WPl0rxUrt4KZ56Xh26_tDxJ08JYHsgpJLt0R9Y9V_VX_Id2Ko</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Kandasamy, Yogavijayan</creator><creator>Smith, Roger</creator><creator>Wright, Ian M. R.</creator><creator>Lumbers, Eugenie R.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity</title><author>Kandasamy, Yogavijayan ; Smith, Roger ; Wright, Ian M. R. ; Lumbers, Eugenie R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c672t-d2710a72491d2ba12787e61a08035af613b253f9e930822eda03b7fcaa4d463a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anthropometry</topic><topic>Autopsies</topic><topic>Birth weight</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Children</topic><topic>Creatinine - blood</topic><topic>Cystatin C - blood</topic><topic>Diseases</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - growth & development</topic><topic>Infant, Small for Gestational Age</topic><topic>Infants (Premature)</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - growth & development</topic><topic>Kidney - pathology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - congenital</topic><topic>Kidney Diseases - diagnostic imaging</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney tubules</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Neonatal care</topic><topic>Nephrology</topic><topic>Nephrons - pathology</topic><topic>Newborn babies</topic><topic>Observational studies</topic><topic>Original</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kandasamy, Yogavijayan</creatorcontrib><creatorcontrib>Smith, Roger</creatorcontrib><creatorcontrib>Wright, Ian M. R.</creatorcontrib><creatorcontrib>Lumbers, Eugenie R.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kandasamy, Yogavijayan</au><au>Smith, Roger</au><au>Wright, Ian M. R.</au><au>Lumbers, Eugenie R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>28</volume><issue>9</issue><spage>1791</spage><epage>1796</epage><pages>1791-1796</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
Nephron number in humans is determined during fetal life. The objective of this study was to investigate the effects of preterm birth on nephron number using renal volume as a surrogate for nephron number.
Methods
This observational study was conducted over 12 months in a tertiary perinatal center. Preterm babies less than 32 weeks of gestation were recruited and followed until discharge. Term infants were recruited for comparison. The babies underwent renal sonography and renal function measurements at 32 and 38 weeks corrected age. The primary outcome measurement was total kidney volume at 38 weeks and the secondary outcome was estimated glomerular filtration rate (eGFR).
Results
Forty-four preterm infants and 24 term infants were recruited. At 38 weeks corrected age, premature infants had lower total kidney volume than term infants (21.6 ± 5.7 vs. 25.2 ± 5.7 ml;
p
= 0.02) and a significantly lower eGFR (73.6 [IQR 68.1–77.6] vs. 79.3 [IQR 72.5–86.6] ml·min
−1
·1.73 m
−2
;
p
= 0.03). There was a significant correlation between total kidney volume and eGFR in premature and term babies.
Conclusions
Premature infants have smaller kidney volume and likely decreased nephron number and lower estimated glomerulofiltration rate relative to infants born at term.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23553045</pmid><doi>10.1007/s00467-013-2462-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2013-09, Vol.28 (9), p.1791-1796 |
| issn | 0931-041X 1432-198X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3722455 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Anthropometry Autopsies Birth weight Blood pressure Blood Pressure - physiology Children Creatinine - blood Cystatin C - blood Diseases Female Gestational Age Glomerular Filtration Rate - physiology Hospitals Humans Infant Infant, Newborn Infant, Premature - growth & development Infant, Small for Gestational Age Infants (Premature) Kidney - diagnostic imaging Kidney - growth & development Kidney - pathology Kidney diseases Kidney Diseases - congenital Kidney Diseases - diagnostic imaging Kidney Diseases - pathology Kidney tubules Male Medical research Medicine Medicine & Public Health Medicine, Experimental Neonatal care Nephrology Nephrons - pathology Newborn babies Observational studies Original Original Article Pediatrics Physiological aspects Premature babies Premature birth Treatment Outcome Ultrasonic imaging Ultrasonography Urology |
| title | Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity |
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