Serotonin and the control of ventilation in awake rats
In awake, unrestrained, intact rats, reserpine, para-chlorophenylalanine, 6-fluorotryptophan, and para-chloroamphetamine depleted whole brain serotonin and produced a substantial and sustained hyperventilation as evidenced by a 5--9 torr drop in PaCO2. Administration of 5-hydroxytryptophan to rats t...
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| Veröffentlicht in: | The Journal of clinical investigation 1979-08, Vol.64 (2), p.689-693 |
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| container_title | The Journal of clinical investigation |
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| creator | Olson, Jr, E B Dempsey, J A McCrimmon, D R |
| description | In awake, unrestrained, intact rats, reserpine, para-chlorophenylalanine, 6-fluorotryptophan, and para-chloroamphetamine depleted whole brain serotonin and produced a substantial and sustained hyperventilation as evidenced by a 5--9 torr drop in PaCO2. Administration of 5-hydroxytryptophan to rats treated with para-chlorophenylalanine partially alleviated the hyperventilation. No change in ventilation was observed after alpha-methyltyrosine. 5,7-Dihydroxytryptamine produced contradictory results. On the basis of these pharmacological studies, we propose that some serotonin-mediated nerve transmissions might function under physiological conditions to inhibit the central nervous system output which controls normal breathing. |
| doi_str_mv | 10.1172/JCI109510 |
| format | Article |
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Administration of 5-hydroxytryptophan to rats treated with para-chlorophenylalanine partially alleviated the hyperventilation. No change in ventilation was observed after alpha-methyltyrosine. 5,7-Dihydroxytryptamine produced contradictory results. On the basis of these pharmacological studies, we propose that some serotonin-mediated nerve transmissions might function under physiological conditions to inhibit the central nervous system output which controls normal breathing.</description><identifier>ISSN: 0021-9738</identifier><identifier>DOI: 10.1172/JCI109510</identifier><identifier>PMID: 156738</identifier><language>eng</language><publisher>United States</publisher><subject>5,7-Dihydroxytryptamine - pharmacology ; Animals ; Brain - metabolism ; Dopamine - metabolism ; Fenclonine - pharmacology ; Hyperventilation - physiopathology ; Male ; Methyltyrosines - pharmacology ; Norepinephrine - metabolism ; p-Chloroamphetamine - pharmacology ; Rats ; Reserpine - pharmacology ; Respiration - drug effects ; Serotonin - metabolism ; Serotonin - pharmacology ; Serotonin - physiology ; Tryptophan - analogs & derivatives ; Tryptophan - pharmacology</subject><ispartof>The Journal of clinical investigation, 1979-08, Vol.64 (2), p.689-693</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-18a91d35b7d51f54598b8ee8eb9ef269c1eb6c5543e939ca0970270963d565cd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC372167/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC372167/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/156738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olson, Jr, E B</creatorcontrib><creatorcontrib>Dempsey, J A</creatorcontrib><creatorcontrib>McCrimmon, D R</creatorcontrib><title>Serotonin and the control of ventilation in awake rats</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>In awake, unrestrained, intact rats, reserpine, para-chlorophenylalanine, 6-fluorotryptophan, and para-chloroamphetamine depleted whole brain serotonin and produced a substantial and sustained hyperventilation as evidenced by a 5--9 torr drop in PaCO2. Administration of 5-hydroxytryptophan to rats treated with para-chlorophenylalanine partially alleviated the hyperventilation. No change in ventilation was observed after alpha-methyltyrosine. 5,7-Dihydroxytryptamine produced contradictory results. On the basis of these pharmacological studies, we propose that some serotonin-mediated nerve transmissions might function under physiological conditions to inhibit the central nervous system output which controls normal breathing.</description><subject>5,7-Dihydroxytryptamine - pharmacology</subject><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Fenclonine - pharmacology</subject><subject>Hyperventilation - physiopathology</subject><subject>Male</subject><subject>Methyltyrosines - pharmacology</subject><subject>Norepinephrine - metabolism</subject><subject>p-Chloroamphetamine - pharmacology</subject><subject>Rats</subject><subject>Reserpine - pharmacology</subject><subject>Respiration - drug effects</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin - physiology</subject><subject>Tryptophan - analogs & derivatives</subject><subject>Tryptophan - pharmacology</subject><issn>0021-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkL1PwzAQxT3wVQoDO0MmJIaAHcd2PDCgio-iSgzAbDnOhRpSu9huEf89Ka0KTCfd_e7uvYfQCcEXhIji8mE0JlgygnfQAOOC5FLQ6gAdxviGMSlLVu6jPcJ43x0g_gTBJ--sy7RrsjSFzHiXgu8y32ZLcMl2OlnvshXxqd8hCzrFI7Tb6i7C8aYO0cvtzfPoPp883o1H15PcUF6lnFRakoayWjSMtKxksqorgApqCW3BpSFQc8NYSUFSaTSWAhcCS04bxplp6BBdre_OF_UMGtPrCbpT82BnOnwpr636P3F2ql79UlFRkN7hEJ1t9oP_WEBMamajga7TDvwiKlFyVkkme_B8DZrgYwzQbn8QrFaxqm2sPXv6V9Qv-ZMp_QZf1HSW</recordid><startdate>19790801</startdate><enddate>19790801</enddate><creator>Olson, Jr, E B</creator><creator>Dempsey, J A</creator><creator>McCrimmon, D R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790801</creationdate><title>Serotonin and the control of ventilation in awake rats</title><author>Olson, Jr, E B ; Dempsey, J A ; McCrimmon, D R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-18a91d35b7d51f54598b8ee8eb9ef269c1eb6c5543e939ca0970270963d565cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>5,7-Dihydroxytryptamine - pharmacology</topic><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Fenclonine - pharmacology</topic><topic>Hyperventilation - physiopathology</topic><topic>Male</topic><topic>Methyltyrosines - pharmacology</topic><topic>Norepinephrine - metabolism</topic><topic>p-Chloroamphetamine - pharmacology</topic><topic>Rats</topic><topic>Reserpine - pharmacology</topic><topic>Respiration - drug effects</topic><topic>Serotonin - metabolism</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin - physiology</topic><topic>Tryptophan - analogs & derivatives</topic><topic>Tryptophan - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olson, Jr, E B</creatorcontrib><creatorcontrib>Dempsey, J A</creatorcontrib><creatorcontrib>McCrimmon, D R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olson, Jr, E B</au><au>Dempsey, J A</au><au>McCrimmon, D R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin and the control of ventilation in awake rats</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1979-08-01</date><risdate>1979</risdate><volume>64</volume><issue>2</issue><spage>689</spage><epage>693</epage><pages>689-693</pages><issn>0021-9738</issn><abstract>In awake, unrestrained, intact rats, reserpine, para-chlorophenylalanine, 6-fluorotryptophan, and para-chloroamphetamine depleted whole brain serotonin and produced a substantial and sustained hyperventilation as evidenced by a 5--9 torr drop in PaCO2. Administration of 5-hydroxytryptophan to rats treated with para-chlorophenylalanine partially alleviated the hyperventilation. No change in ventilation was observed after alpha-methyltyrosine. 5,7-Dihydroxytryptamine produced contradictory results. On the basis of these pharmacological studies, we propose that some serotonin-mediated nerve transmissions might function under physiological conditions to inhibit the central nervous system output which controls normal breathing.</abstract><cop>United States</cop><pmid>156738</pmid><doi>10.1172/JCI109510</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of clinical investigation, 1979-08, Vol.64 (2), p.689-693 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | 5,7-Dihydroxytryptamine - pharmacology Animals Brain - metabolism Dopamine - metabolism Fenclonine - pharmacology Hyperventilation - physiopathology Male Methyltyrosines - pharmacology Norepinephrine - metabolism p-Chloroamphetamine - pharmacology Rats Reserpine - pharmacology Respiration - drug effects Serotonin - metabolism Serotonin - pharmacology Serotonin - physiology Tryptophan - analogs & derivatives Tryptophan - pharmacology |
| title | Serotonin and the control of ventilation in awake rats |
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