A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas

Background: Oesophageal adenocarcinomas often show resistances to chemotherapy (CTX), therefore, it would be of high interest to better understand the mechanisms of resistance. We examined the expression of heat-shock proteins (HSPs) and glucose-regulated proteins (GRPs) in pretherapeutic biopsies o...

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Veröffentlicht in:	British journal of cancer 2013-07, Vol.109 (2), p.370-378
Hauptverfasser:	Slotta-Huspenina, J, Wolff, C, Drecoll, E, Feith, M, Bettstetter, M, Malinowsky, K, Bauer, L, Becker, K, Ott, K, Höfler, H, Becker, K-F, Langer, R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 631/67/1059/99 631/67/1504/1477 Adenocarcinoma - diagnosis Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - mortality Adult Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Biological and medical sciences Biomarkers, Pharmacological - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Biopsy Cancer Research Cancer therapies Chemotherapy Drug Resistance Epidemiology Esophageal Neoplasms - diagnosis Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - mortality Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Glucose Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Immunohistochemistry Male Medical prognosis Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoadjuvant Therapy Oncology Pathology Protein Array Analysis Protein expression Reverse Transcriptase Polymerase Chain Reaction Surgery Survival Analysis Transcriptome - physiology Translational Therapeutics Tumors
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