Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles....
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| Veröffentlicht in: | Journal of nanobiotechnology 2013-07, Vol.11 (1), p.26-26, Article 26 |
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| container_title | Journal of nanobiotechnology |
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| creator | Saptarshi, Shruti R Duschl, Albert Lopata, Andreas L |
| description | Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake. |
| doi_str_mv | 10.1186/1477-3155-11-26 |
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This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. 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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Saptarshi et al.; licensee BioMed Central Ltd. 2013 Saptarshi et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-ee91715f0aebc5bd88c8a9cc62aaa490679f69f305e3c528de0a9d9483b4b3913</citedby><cites>FETCH-LOGICAL-c555t-ee91715f0aebc5bd88c8a9cc62aaa490679f69f305e3c528de0a9d9483b4b3913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720198/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720198/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23870291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saptarshi, Shruti R</creatorcontrib><creatorcontrib>Duschl, Albert</creatorcontrib><creatorcontrib>Lopata, Andreas L</creatorcontrib><title>Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle</title><title>Journal of nanobiotechnology</title><addtitle>J Nanobiotechnology</addtitle><description>Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake.</description><subject>Adsorption</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological research</subject><subject>Biology, Experimental</subject><subject>Cells - metabolism</subject><subject>Denaturation</subject><subject>Humans</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Plasma</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Proteins - chemistry</subject><subject>Proteins - metabolism</subject><subject>Review</subject><subject>Zinc oxides</subject><issn>1477-3155</issn><issn>1477-3155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkktv1DAUhS0Eog9Ys0OR2NBFWj8Tm0WlquIxUiUkHhs2luPczLjK2IPtFPrvcWgZGoS8sH39neNr6yD0guBTQmRzRnjb1owIURNS0-YROtxXHj9YH6CjlK4xppRT_hQdUCZbTBU5RN9WPkM0NrvgqzBU3viwMzE7O0Kqfri8qXYxZHA-vakijOY3mEPVuVBHmIU3Lt_O0ryBhfwZejKYMcHz-_kYfX339svlh_rq4_vV5cVVbYUQuQZQpCViwAY6K7peSiuNsrahxhiucNOqoVEDwwKYFVT2gI3qFZes4x1ThB2j8zvf3dRtobfgczSj3kW3NfFWB-P08sS7jV6HG81aiomSxeD1vUEM3ydIWW9dsjCOxkOYkiacKNaS0mZBX_2DXocp-vK8mWKYc9HKv9TajKCdH0K5186m-kIw3jRC8bnv0_9QZfSwdTZ4GFypLwQnC0FhMvzMazOlpFefPy3ZszvWxpBShGH_HwTrOTp6Doeew1G2mjZF8fLhN-75P1lhvwBZ473k</recordid><startdate>20130719</startdate><enddate>20130719</enddate><creator>Saptarshi, Shruti R</creator><creator>Duschl, Albert</creator><creator>Lopata, Andreas L</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QO</scope><scope>7TB</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130719</creationdate><title>Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle</title><author>Saptarshi, Shruti R ; 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| subjects | Adsorption Animals Biochemistry Biological research Biology, Experimental Cells - metabolism Denaturation Humans Nanomaterials Nanoparticles Nanoparticles - chemistry Nanotechnology NMR Nuclear magnetic resonance Plasma Protein Binding Proteins Proteins - chemistry Proteins - metabolism Review Zinc oxides |
| title | Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle |
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