The inhibitory effects of NKX3.1 on IGF-1R expression and its signalling pathway in human prostatic carcinoma PC3 cells

NKX3.1, which is a prostate-specific homeobox gene, plays an important role in prostate cancer and usually functions as a tumour suppressor gene. In this study, we investigated the inhibitory effect of NKX3.1 on insulin-like growth factor (IGF)-1R expression and its downstream signalling pathway in...

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Veröffentlicht in:	Asian journal of andrology 2012-05, Vol.14 (3), p.493-498
Hauptverfasser:	Zhang, Peng-Ju, Hu, Xiao-Yan, Liu, Chun-Yan, Chen, Zhao-Bo, Ni, Na-Na, Yu, Yang, Yang, Li-Na, Huang, Zhao-Qin, Liu, Qing-Wei, Jiang, An-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Cell Line, Tumor Cell Proliferation - drug effects Down-Regulation Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Insulin-Like Growth Factor I - pharmacology Male Original Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transfection
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