Controlling immune response and demyelination using highly potent bifunctional peptide inhibitors in the suppression of experimental autoimmune encephalomyelitis

Summary In this study, we investigated the efficacy of new bifunctional peptide inhibitors (BPIs) in suppressing experimental autoimmune encephalomyelitis (EAE) in an animal model. BPI [e.g. proteolipid protein–cyclo(1,8)‐CPRGGSVC‐NH2 (PLP‐cIBR)] is a conjugate between the PLP139–151 peptide derived...

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Veröffentlicht in:	Clinical and experimental immunology 2013-04, Vol.172 (1), p.23-36
Hauptverfasser:	Kiptoo, P., Büyüktimkin, B., Badawi, A. H., Stewart, J., Ridwan, R., Siahaan, T. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens - immunology antigen‐presenting cell bifunctional peptide inhibitor Cytokines Cytokines - biosynthesis Cytokines - immunology EAE Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Female Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Immune Tolerance - drug effects Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - immunology leucocyte infiltration Leukocytes lovastatin Lymphocyte Function-Associated Antigen-1 - genetics Lymphocyte Function-Associated Antigen-1 - immunology Mice Molecular Sequence Data Mutant Chimeric Proteins - chemical synthesis Mutant Chimeric Proteins - immunology Mutant Chimeric Proteins - pharmacology Myelin Proteolipid Protein - chemistry Myelin Proteolipid Protein - immunology Myelin Sheath - drug effects Myelin Sheath - immunology Myelin Sheath - pathology Neuroprotective Agents - chemical synthesis Neuroprotective Agents - immunology Neuroprotective Agents - pharmacology Original Peptide Fragments - chemistry Peptide Fragments - immunology Peptides T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - pathology
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