Tumour necrosis factor receptors and apoptosis of alveolar macrophages during early infection with attenuated and virulent Mycobacterium bovis

Summary Apoptosis of macrophages has been reported as an effective host strategy to control the growth of intracellular pathogens, including pathogenic mycobacteria. Tumour necrosis factor‐α (TNF‐α) plays an important role in the modulation of apoptosis of infected macrophages. It exerts its biologi...

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Veröffentlicht in:	Immunology 2013-08, Vol.139 (4), p.503-512
Hauptverfasser:	Rodrigues, Michele F., Alves, Caio C. S., Figueiredo, Bárbara B. M., Rezende, Alice B., Wohlres‐Viana, Sabine, Silva, Vânia Lúcia da, Machado, Marco Antônio, Teixeira, Henrique C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Line Cell Membrane - immunology Cell Membrane - microbiology macrophage Macrophages, Alveolar - immunology Macrophages, Alveolar - microbiology Macrophages, Alveolar - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium bovis Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity Original Receptors, Tumor Necrosis Factor, Type I - deficiency Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - metabolism Signal Transduction Time Factors Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - pathology Tumor Necrosis Factor-alpha - metabolism tumour necrosis factor receptor 1 tumour necrosis factor receptor 2 Virulence
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