Role of nociceptor αCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats

We have previously shown that activation of protein kinase Cε (PKCε) in male rats induces a chronic, long-lasting change in nociceptors such that a subsequent exposure to proinflammatory mediators produces markedly prolonged mechanical hyperalgesia. This neuroplastic change, hyperalgesic priming, is...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of neuroscience 2013-07, Vol.33 (27), p.11002-11011
Hauptverfasser:	Ferrari, Luiz F, Bogen, Oliver, Levine, Jon D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Pain - metabolism Acute Pain - pathology Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Chronic Pain - metabolism Chronic Pain - pathology Female Hyperalgesia - metabolism Hyperalgesia - pathology Male Nociceptors - physiology Pain Measurement - methods Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!