Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants With Type 2 Diabetes in American Indians

Parent-of-origin effects were observed in an Icelandic population for several genetic variants associated with type 2 diabetes, including those in KLF14 (rs4731702), MOB2 (rs2334499), and KCNQ1 (rs2237892, rs231362). We analyzed parent-of-origin effects for these variants, along with two others in K...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-08, Vol.62 (8), p.2984-2991
Hauptverfasser:	HANSON, Robert L, TINGWEI GUO, MULLER, Yunhua L, FLEMING, Jamie, KNOWLER, William C, KOBES, Sayuko, BOGARDUS, Clifton, BAIER, Leslie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Analysis Biological and medical sciences Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Genetic Association Studies Genetic Predisposition to Disease Genetics Genomics Genotype Glucose Glucose metabolism Glucose Tolerance Test Glucose tolerance tests Haplotypes Health aspects Humans Indians, North American - genetics Insulin Insulin - genetics Insulin - metabolism Insulin Secretion KCNQ1 Potassium Channel - genetics Kruppel-Like Transcription Factors Longitudinal Studies Male Medical sciences Native Americans Native North Americans Nerve Tissue Proteins - genetics Original Research Parents Polymorphism, Single Nucleotide Sp Transcription Factors - genetics Type 2 diabetes
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