A Role for Hypocretin/Orexin Receptor-1 in Cue-Induced Reinstatement of Nicotine-Seeking Behavior

Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by nicotine-associated cues. Pretreatment with the hypocretin receptor-1 antagoni...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2013-08, Vol.38 (9), p.1724-1736
Hauptverfasser:	PLAZA-ZABALA, Ainhoa, FLORES, África, MARTIN-GARCIA, Elena, SARAVIA, Rocío, MALDONADO, Rafael, BERRENDERO, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Addicció Animals Benzoxazoles - pharmacology Biological and medical sciences Catheters Conditioning, Operant - drug effects Conditioning, Operant - physiology Cortex (prefrontal) Cues Drug-Seeking Behavior - drug effects Drug-Seeking Behavior - physiology Extinction, Psychological - drug effects Extinction, Psychological - physiology Farmacologia Food Health sciences Hypothalamus - drug effects Hypothalamus - physiology Isoquinolines - pharmacology Ketamine Kinases Laboratory animals Male Medical sciences Mice Microinjections Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - physiology Nicotina Nicotine Nicotine - administration & dosage Nicotine - pharmacology Nicotinic Agonists - administration & dosage Nicotinic Agonists - pharmacology Nucleus Accumbens - metabolism Orexin Receptor Antagonists Orexin Receptors - physiology Original p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Physiology Piperidines - administration & dosage Piperidines - pharmacology Prefrontal Cortex - metabolism Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Self Administration Signal Transduction - drug effects Signal Transduction - physiology Tobacco Urea - analogs & derivatives Urea - pharmacology
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