Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type
The mechanisms governing the expansion of neuron number in specific brain regions are still poorly understood. Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial g...
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| Veröffentlicht in: | Nature communications 2013-07, Vol.4 (1), p.2125-2125, Article 2125 |
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| creator | Pilz, Gregor-Alexander Shitamukai, Atsunori Reillo, Isabel Pacary, Emilie Schwausch, Julia Stahl, Ronny Ninkovic, Jovica Snippert, Hugo J. Clevers, Hans Godinho, Leanne Guillemot, Francois Borrell, Victor Matsuzaki, Fumio Götz, Magdalena |
| description | The mechanisms governing the expansion of neuron number in specific brain regions are still poorly understood. Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial glial cells and their progeny in the ventral telencephalon, the region with the largest subventricular zone in the murine brain during neurogenesis. We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further proliferating progeny. The frequency of this new type of progenitor is increased not only in larger clones of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated species, and upon inducing gyrification in the murine cerebral cortex. This implies key roles of this new type of radial glia in ontogeny and phylogeny.
Amplification of neural progenitor cells mediates expansion of brain regions. Using imaging of progenitor cell amplification in the mouse ventral forebrain, the authors identify a new progenitor type with high frequency, which they also show to be present in expanded brain regions of other species. |
| doi_str_mv | 10.1038/ncomms3125 |
| format | Article |
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Amplification of neural progenitor cells mediates expansion of brain regions. Using imaging of progenitor cell amplification in the mouse ventral forebrain, the authors identify a new progenitor type with high frequency, which they also show to be present in expanded brain regions of other species.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms3125</identifier><identifier>PMID: 23839311</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/368 ; 631/378/2571/219 ; Animals ; Cell Differentiation ; Cell Lineage - physiology ; Cell Proliferation ; Embryo, Mammalian ; Ependymoglial Cells - cytology ; Ependymoglial Cells - metabolism ; Genes, Reporter ; Green Fluorescent Proteins ; Humanities and Social Sciences ; Mice ; Mice, Transgenic ; multidisciplinary ; Neural Stem Cells - cytology ; Neural Stem Cells - metabolism ; Neurogenesis ; Neurons - cytology ; Neurons - metabolism ; Science ; Science (multidisciplinary) ; Telencephalon - cytology ; Telencephalon - embryology ; Telencephalon - metabolism ; Time-Lapse Imaging ; Tissue Culture Techniques</subject><ispartof>Nature communications, 2013-07, Vol.4 (1), p.2125-2125, Article 2125</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group Jul 2013</rights><rights>Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-1a6a5674f025d05210af8403abe8cea69e71a74eef6da06356588a898ad520c93</citedby><cites>FETCH-LOGICAL-c508t-1a6a5674f025d05210af8403abe8cea69e71a74eef6da06356588a898ad520c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717501/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717501/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23839311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilz, Gregor-Alexander</creatorcontrib><creatorcontrib>Shitamukai, Atsunori</creatorcontrib><creatorcontrib>Reillo, Isabel</creatorcontrib><creatorcontrib>Pacary, Emilie</creatorcontrib><creatorcontrib>Schwausch, Julia</creatorcontrib><creatorcontrib>Stahl, Ronny</creatorcontrib><creatorcontrib>Ninkovic, Jovica</creatorcontrib><creatorcontrib>Snippert, Hugo J.</creatorcontrib><creatorcontrib>Clevers, Hans</creatorcontrib><creatorcontrib>Godinho, Leanne</creatorcontrib><creatorcontrib>Guillemot, Francois</creatorcontrib><creatorcontrib>Borrell, Victor</creatorcontrib><creatorcontrib>Matsuzaki, Fumio</creatorcontrib><creatorcontrib>Götz, Magdalena</creatorcontrib><title>Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>The mechanisms governing the expansion of neuron number in specific brain regions are still poorly understood. Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial glial cells and their progeny in the ventral telencephalon, the region with the largest subventricular zone in the murine brain during neurogenesis. We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further proliferating progeny. The frequency of this new type of progenitor is increased not only in larger clones of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated species, and upon inducing gyrification in the murine cerebral cortex. This implies key roles of this new type of radial glia in ontogeny and phylogeny.
Amplification of neural progenitor cells mediates expansion of brain regions. Using imaging of progenitor cell amplification in the mouse ventral forebrain, the authors identify a new progenitor type with high frequency, which they also show to be present in expanded brain regions of other species.</description><subject>631/136/368</subject><subject>631/378/2571/219</subject><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cell Lineage - physiology</subject><subject>Cell Proliferation</subject><subject>Embryo, Mammalian</subject><subject>Ependymoglial Cells - cytology</subject><subject>Ependymoglial Cells - metabolism</subject><subject>Genes, Reporter</subject><subject>Green Fluorescent Proteins</subject><subject>Humanities and Social Sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>multidisciplinary</subject><subject>Neural Stem Cells - cytology</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neurogenesis</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Telencephalon - cytology</subject><subject>Telencephalon - embryology</subject><subject>Telencephalon - metabolism</subject><subject>Time-Lapse Imaging</subject><subject>Tissue Culture Techniques</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU2LFDEQhoMo7rLuxR8gAS-ijFY6ne70RVgWv2DBi55Dbbp6Jks-2qRb2X9vxlnXUXNIKtTDW_XyMvZUwGsBUr-JNoVQpGjUA3baQCs2om_kw6P6hJ2XcgP1yEHotn3MThqp5SCFOGV4EWbvJmdxcSnyNPE5py1Ft6RcuIt82REPGAJ6h_VHnqKleYe-0i5av45UOPJIP3jG0aHnW7-_LXnPl9uZnrBHE_pC53fvGfv6_t2Xy4-bq88fPl1eXG2sAr1sBHaour6doFEjqEYATroFidekLWE3UC-wb4mmbkTopOqU1qgHjaNqwA7yjL096M7rdaDRUlwyejNnFzDfmoTO_N2Jbme26buRvegViCrw4k4gp28rlcUEV_Y2MFJaixFyGBS0WkNFn_-D3qQ1x2rvFyWg60FW6uWBsjmVkmm6X0aA2Ydn_oRX4WfH69-jv6OqwKsDUGorbikfzfxf7idoDaXH</recordid><startdate>20130710</startdate><enddate>20130710</enddate><creator>Pilz, Gregor-Alexander</creator><creator>Shitamukai, Atsunori</creator><creator>Reillo, Isabel</creator><creator>Pacary, Emilie</creator><creator>Schwausch, Julia</creator><creator>Stahl, Ronny</creator><creator>Ninkovic, Jovica</creator><creator>Snippert, Hugo J.</creator><creator>Clevers, Hans</creator><creator>Godinho, Leanne</creator><creator>Guillemot, Francois</creator><creator>Borrell, Victor</creator><creator>Matsuzaki, Fumio</creator><creator>Götz, Magdalena</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Pub. 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Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial glial cells and their progeny in the ventral telencephalon, the region with the largest subventricular zone in the murine brain during neurogenesis. We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further proliferating progeny. The frequency of this new type of progenitor is increased not only in larger clones of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated species, and upon inducing gyrification in the murine cerebral cortex. This implies key roles of this new type of radial glia in ontogeny and phylogeny.
Amplification of neural progenitor cells mediates expansion of brain regions. Using imaging of progenitor cell amplification in the mouse ventral forebrain, the authors identify a new progenitor type with high frequency, which they also show to be present in expanded brain regions of other species.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23839311</pmid><doi>10.1038/ncomms3125</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136/368 631/378/2571/219 Animals Cell Differentiation Cell Lineage - physiology Cell Proliferation Embryo, Mammalian Ependymoglial Cells - cytology Ependymoglial Cells - metabolism Genes, Reporter Green Fluorescent Proteins Humanities and Social Sciences Mice Mice, Transgenic multidisciplinary Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis Neurons - cytology Neurons - metabolism Science Science (multidisciplinary) Telencephalon - cytology Telencephalon - embryology Telencephalon - metabolism Time-Lapse Imaging Tissue Culture Techniques |
| title | Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type |
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