Clinicopathological significance of claudin-4 in gastric carcinoma
Aberrant expression of claudin proteins has been reported in a variety of cancers. Previous studies have demonstrated that overexpression of claudin may promote tumorigenesis and metastasis through increased invasion and survival of tumor cells. However, the prognostic significance of claudin-4 in g...
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| Veröffentlicht in: | World journal of surgical oncology 2013-07, Vol.11 (1), p.150-150, Article 150 |
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| description | Aberrant expression of claudin proteins has been reported in a variety of cancers. Previous studies have demonstrated that overexpression of claudin may promote tumorigenesis and metastasis through increased invasion and survival of tumor cells. However, the prognostic significance of claudin-4 in gastric cancer remains unclear.
Immunohistochemistry was used to analyze the expression of claudin-4 in 329 clinical gastric cancer specimens and 44 normal stomach samples, 21 intestinal metaplasia samples, and 21 adjacent precursor lesions dysplasia samples. Statistical analysis methods were used to evaluate the relationship between claudin-4 expression and various clinicopathological parameters. Univariate and multivariate analyses were performed, respectively, to detect the independent predictors of survival.
Claudin-4 expression was present in only 7(15.9%) normal gastric samples, but expression of claudin-4 in the intestinal metaplasia lesions and dysplasia lesions was 90.5% and 95.2%, respectively. The expression of claudin-4 was significantly associated with histological differentiation (P |
| doi_str_mv | 10.1186/1477-7819-11-150 |
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Immunohistochemistry was used to analyze the expression of claudin-4 in 329 clinical gastric cancer specimens and 44 normal stomach samples, 21 intestinal metaplasia samples, and 21 adjacent precursor lesions dysplasia samples. Statistical analysis methods were used to evaluate the relationship between claudin-4 expression and various clinicopathological parameters. Univariate and multivariate analyses were performed, respectively, to detect the independent predictors of survival.
Claudin-4 expression was present in only 7(15.9%) normal gastric samples, but expression of claudin-4 in the intestinal metaplasia lesions and dysplasia lesions was 90.5% and 95.2%, respectively. The expression of claudin-4 was significantly associated with histological differentiation (P < 0.001) and tumor growth patterns (P < 0.001) but not associated with patient survival. However, intermediate type staining of claudin-4 exhibited a trend of correlation with patients' survival (P = 0.023). The five-year survival rate with low expression of claudin-4 in intermediate type (76.4%) was similar to expanding type (64.5%), while the high expression group (46.6%) was closer to infiltrative type (50.7%).
The findings in this study demonstrate claudin-4 aberrant expression in gastric cancer and precursor lesions. The expression of claudin-4 could serve as a basis for identifying gastric cancer of the intermediate type.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/1477-7819-11-150</identifier><identifier>PMID: 23822740</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Cancer ; Carcinoma ; Care and treatment ; Classification ; Claudin-4 - metabolism ; Committees ; Female ; Follow-Up Studies ; Gastric cancer ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Gene expression ; Genetic aspects ; Humans ; Immunoenzyme Techniques ; Infections ; Lymphatic Metastasis ; Male ; Metaplasia - metabolism ; Metaplasia - mortality ; Metaplasia - pathology ; Metastasis ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncology ; Oncology, Experimental ; Physiological aspects ; Prognosis ; Proteins ; Signal transduction ; Statistical analysis ; Stomach cancer ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Survival analysis ; Survival Rate</subject><ispartof>World journal of surgical oncology, 2013-07, Vol.11 (1), p.150-150, Article 150</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Zhu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2013 Zhu et al.; licensee BioMed Central Ltd. 2013 Zhu et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b648t-d803a49a152ce2ebe42603fdc273c1e896fcb8189454096b7e1785015dd654123</citedby><cites>FETCH-LOGICAL-b648t-d803a49a152ce2ebe42603fdc273c1e896fcb8189454096b7e1785015dd654123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717126/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717126/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23822740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Jin-Liang</creatorcontrib><creatorcontrib>Gao, Peng</creatorcontrib><creatorcontrib>Wang, Zhen-Ning</creatorcontrib><creatorcontrib>Song, Yong-Xi</creatorcontrib><creatorcontrib>Li, Ai-Lin</creatorcontrib><creatorcontrib>Xu, Ying-Ying</creatorcontrib><creatorcontrib>Wang, Mei-Xian</creatorcontrib><creatorcontrib>Xu, Hui-Mian</creatorcontrib><title>Clinicopathological significance of claudin-4 in gastric carcinoma</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>Aberrant expression of claudin proteins has been reported in a variety of cancers. Previous studies have demonstrated that overexpression of claudin may promote tumorigenesis and metastasis through increased invasion and survival of tumor cells. However, the prognostic significance of claudin-4 in gastric cancer remains unclear.
Immunohistochemistry was used to analyze the expression of claudin-4 in 329 clinical gastric cancer specimens and 44 normal stomach samples, 21 intestinal metaplasia samples, and 21 adjacent precursor lesions dysplasia samples. Statistical analysis methods were used to evaluate the relationship between claudin-4 expression and various clinicopathological parameters. Univariate and multivariate analyses were performed, respectively, to detect the independent predictors of survival.
Claudin-4 expression was present in only 7(15.9%) normal gastric samples, but expression of claudin-4 in the intestinal metaplasia lesions and dysplasia lesions was 90.5% and 95.2%, respectively. The expression of claudin-4 was significantly associated with histological differentiation (P < 0.001) and tumor growth patterns (P < 0.001) but not associated with patient survival. However, intermediate type staining of claudin-4 exhibited a trend of correlation with patients' survival (P = 0.023). The five-year survival rate with low expression of claudin-4 in intermediate type (76.4%) was similar to expanding type (64.5%), while the high expression group (46.6%) was closer to infiltrative type (50.7%).
The findings in this study demonstrate claudin-4 aberrant expression in gastric cancer and precursor lesions. The expression of claudin-4 could serve as a basis for identifying gastric cancer of the intermediate type.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Care and treatment</subject><subject>Classification</subject><subject>Claudin-4 - metabolism</subject><subject>Committees</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Infections</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Metaplasia - metabolism</subject><subject>Metaplasia - mortality</subject><subject>Metaplasia - pathology</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Statistical analysis</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kk2LFDEQhoMo7rp69yQNguyl11S--yKsw_oBC170HNLpdE-WdDJ2uhf896aZdZyRlRxSVD31JrxVCL0GfAWgxHtgUtZSQVMD1MDxE3R-SD09is_Qi5zvMCaUcvocnRGqCJEMn6OPm-Cjt2ln5m0KafDWhCr7Ifq-hNG6KvWVDWbpfKxZ5WM1mDxP3lbWTNbHNJqX6FlvQnavHu4L9OPTzffNl_r22-evm-vbuhVMzXWnMDWsMcCJdcS1jhGBad9ZIqkFpxrR21aBahhnuBGtdCAVx8C7TnAGhF6gD3vd3dKOrrMuzpMJejf50Uy_dDJen1ai3-oh3WsqQQIRRWCzF2h9-o_AacWmUa8e6tVDDaCLxUXl8uEbU_q5uDzr0WfrQjDRpSWXBgBBOSasoG__Qe_SMsVi0koRKiRh4i81mOC0j30qj9tVVF9zyoRQjPBCXT1CldO5scwvut6X_EnDu6OGrTNh3uYUltmnmE9BvAftlHKeXH9wBLBe1-wxD94cj-LQ8Gev6G8YZMp2</recordid><startdate>20130704</startdate><enddate>20130704</enddate><creator>Zhu, Jin-Liang</creator><creator>Gao, Peng</creator><creator>Wang, Zhen-Ning</creator><creator>Song, Yong-Xi</creator><creator>Li, Ai-Lin</creator><creator>Xu, Ying-Ying</creator><creator>Wang, Mei-Xian</creator><creator>Xu, Hui-Mian</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130704</creationdate><title>Clinicopathological significance of claudin-4 in gastric carcinoma</title><author>Zhu, Jin-Liang ; Gao, Peng ; Wang, Zhen-Ning ; Song, Yong-Xi ; Li, Ai-Lin ; Xu, Ying-Ying ; Wang, Mei-Xian ; Xu, Hui-Mian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b648t-d803a49a152ce2ebe42603fdc273c1e896fcb8189454096b7e1785015dd654123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Care and treatment</topic><topic>Classification</topic><topic>Claudin-4 - metabolism</topic><topic>Committees</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Infections</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Metaplasia - metabolism</topic><topic>Metaplasia - mortality</topic><topic>Metaplasia - pathology</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Physiological aspects</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Statistical analysis</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Survival analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Jin-Liang</creatorcontrib><creatorcontrib>Gao, Peng</creatorcontrib><creatorcontrib>Wang, Zhen-Ning</creatorcontrib><creatorcontrib>Song, Yong-Xi</creatorcontrib><creatorcontrib>Li, Ai-Lin</creatorcontrib><creatorcontrib>Xu, Ying-Ying</creatorcontrib><creatorcontrib>Wang, Mei-Xian</creatorcontrib><creatorcontrib>Xu, Hui-Mian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Jin-Liang</au><au>Gao, Peng</au><au>Wang, Zhen-Ning</au><au>Song, Yong-Xi</au><au>Li, Ai-Lin</au><au>Xu, Ying-Ying</au><au>Wang, Mei-Xian</au><au>Xu, Hui-Mian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological significance of claudin-4 in gastric carcinoma</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2013-07-04</date><risdate>2013</risdate><volume>11</volume><issue>1</issue><spage>150</spage><epage>150</epage><pages>150-150</pages><artnum>150</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>Aberrant expression of claudin proteins has been reported in a variety of cancers. Previous studies have demonstrated that overexpression of claudin may promote tumorigenesis and metastasis through increased invasion and survival of tumor cells. However, the prognostic significance of claudin-4 in gastric cancer remains unclear.
Immunohistochemistry was used to analyze the expression of claudin-4 in 329 clinical gastric cancer specimens and 44 normal stomach samples, 21 intestinal metaplasia samples, and 21 adjacent precursor lesions dysplasia samples. Statistical analysis methods were used to evaluate the relationship between claudin-4 expression and various clinicopathological parameters. Univariate and multivariate analyses were performed, respectively, to detect the independent predictors of survival.
Claudin-4 expression was present in only 7(15.9%) normal gastric samples, but expression of claudin-4 in the intestinal metaplasia lesions and dysplasia lesions was 90.5% and 95.2%, respectively. The expression of claudin-4 was significantly associated with histological differentiation (P < 0.001) and tumor growth patterns (P < 0.001) but not associated with patient survival. However, intermediate type staining of claudin-4 exhibited a trend of correlation with patients' survival (P = 0.023). The five-year survival rate with low expression of claudin-4 in intermediate type (76.4%) was similar to expanding type (64.5%), while the high expression group (46.6%) was closer to infiltrative type (50.7%).
The findings in this study demonstrate claudin-4 aberrant expression in gastric cancer and precursor lesions. The expression of claudin-4 could serve as a basis for identifying gastric cancer of the intermediate type.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23822740</pmid><doi>10.1186/1477-7819-11-150</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of surgical oncology, 2013-07, Vol.11 (1), p.150-150, Article 150 |
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| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cancer Carcinoma Care and treatment Classification Claudin-4 - metabolism Committees Female Follow-Up Studies Gastric cancer Gastric Mucosa - metabolism Gastric Mucosa - pathology Gene expression Genetic aspects Humans Immunoenzyme Techniques Infections Lymphatic Metastasis Male Metaplasia - metabolism Metaplasia - mortality Metaplasia - pathology Metastasis Middle Aged Neoplasm Invasiveness Neoplasm Staging Oncology Oncology, Experimental Physiological aspects Prognosis Proteins Signal transduction Statistical analysis Stomach cancer Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Survival analysis Survival Rate |
| title | Clinicopathological significance of claudin-4 in gastric carcinoma |
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