The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies

Despite the use of highly active antiretroviral therapy (HAART), AIDS-related lymphoma remains common. We investigated the tumor, microenvironment, and viral components in 41 AIDS-related diffuse large B-cell lymphomas (AR-DLBCLs) in the pre- and post-HAART era. The outcome has improved and the freq...

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Veröffentlicht in:	Blood 2013-07, Vol.122 (3), p.424-433
Hauptverfasser:	Liapis, Konstantinos, Clear, Andrew, Owen, Andrew, Coutinho, Rita, Greaves, Paul, Lee, Abigail M., Montoto, Silvia, Calaminici, Maria, Gribben, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - pathology Acquired Immunodeficiency Syndrome - virology Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Blood Vessels - pathology Cellular Senescence - immunology Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - pathology Female Gene Rearrangement - genetics Herpesvirus 4, Human - physiology HIV-1 - physiology Humans Lymphocytes, Tumor-Infiltrating - pathology Lymphocytes, Tumor-Infiltrating - virology Lymphoid Neoplasia Lymphoma, AIDS-Related - drug therapy Lymphoma, AIDS-Related - pathology Lymphoma, Large B-Cell, Diffuse - complications Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large B-Cell, Diffuse - virology Macrophages - pathology Male Middle Aged Neovascularization, Pathologic - complications Neovascularization, Pathologic - pathology Proto-Oncogene Proteins c-myc - metabolism Tumor Microenvironment Young Adult
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