Mechanism by which bile salt disrupts the gastric mucosal barrier in the dog

Bile salts disrupt a functional "gastric mucosal barrier" increasing net forward-diffusion (+) of Na+ and back-diffusion (-) of H+. Studying canine Heidenhain pouches, we attempted to distinguish between two possible mechanisms for this effect: (a) mucosal uptake of bile salt with subseque...

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Veröffentlicht in:	The Journal of clinical investigation 1980-11, Vol.66 (5), p.1044-1049
Hauptverfasser:	Duane, W C, Wiegand, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - physiology Cholesterol - metabolism Diffusion Dogs Gastric Mucosa - metabolism Humans Hydrogen - metabolism Phospholipids - metabolism Sodium - metabolism
Online-Zugang:	Volltext
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