Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis–based study of 428 cases

Summary Prostate cancer remains a major health problem in the United States. Established clinicopathologic parameters such as Gleason score, T stage, and prostate-specific antigen levels are currently the guiding tools for prognostication and disease management. The addition of biomarkers could incr...

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Veröffentlicht in:	Human pathology 2012-11, Vol.43 (11), p.1852-1865
Hauptverfasser:	Toubaji, Antoun, MD, Sutcliffe, Siobhan, PhD, Chaux, Alcides, MD, Lecksell, Kristen, BS, Hicks, Jessica, MS, De Marzo, Angelo M., MD, PhD, Platz, Elizabeth A., ScD, MPH, Netto, George J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Adenocarcinoma - therapy Adult Aged Antigens Biochemical recurrence Biological and medical sciences Biomarkers Biomarkers, Tumor - metabolism Cancer-specific death Cell Cycle Proteins - metabolism Cell growth Combined Modality Therapy Deoxyribonucleic acid Disease Disease Progression DNA Gynecology. Andrology. Obstetrics Humans Image Interpretation, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Ki-67 Ki-67 Antigen - metabolism Laboratories Lymphatic Metastasis Male Male genital diseases MCM2 Medical sciences Middle Aged Minichromosome Maintenance Complex Component 2 Mortality Neoplasm Recurrence, Local - diagnosis Nephrology. Urinary tract diseases Nuclear Proteins - metabolism Open source software Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Patients Prognosis Prostate cancer Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Proteins Scanners Statistical data Studies Survival analysis Survival Rate Tissue Array Analysis Tumors Tumors of the urinary system Urinary tract. Prostate gland
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