Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients
Purpose To report the 5-year results of a prospective trial of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation in the prone position. Methods and Materials Postmenopausal patients with Stage I breast cancer with nonpalpable tumors
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2012-11, Vol.84 (3), p.606-611 |
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| creator | Formenti, Silvia C., M.D Hsu, Howard, M.D Fenton-Kerimian, Maria, N.P Roses, Daniel, M.D Guth, Amber, M.D Jozsef, Gabor, Ph.D Goldberg, Judith D., Sc.D DeWyngaert, J. Keith, Ph.D |
| description | Purpose To report the 5-year results of a prospective trial of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation in the prone position. Methods and Materials Postmenopausal patients with Stage I breast cancer with nonpalpable tumors |
| doi_str_mv | 10.1016/j.ijrobp.2012.01.039 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3714845</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0360301612000831</els_id><sourcerecordid>1074769575</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-c401cc3b261c91e4747bf7e39521e1bee62031d2013a9a49c7407d8c01cbab733</originalsourceid><addsrcrecordid>eNqFUsGO0zAQjRCILQt_gFAkhMQlxRM7ccMBqVQsrLQSKxYkbpbjTLouqV3GTqX-PY5adoELpznMe2_mzZssew5sDgzqN5u53ZBvd_OSQTlnMGe8eZDNYCGbglfV94fZjPGaFTyBz7InIWwYYwBSPM7OylI0olo0s8xfk3eYL43BAUlH7PJrTdHqIX9PqEPML4l0Z3W03uXLPiKdGsXKu4C0t26d34y0Rjq8zS_sHosDasq_YBiHGHLf58BYEo0WXQxPs0e9HgI-O9Xz7NvFh6-rT8XV54-Xq-VVYSpZx8IIBsbwtqzBNIBCCtn2EnlTlYDQItYl49Al61w3WjRGCia7hUmsVreS8_Ps3VF3N7Zb7EyaTXpQO7JbTQfltVV_d5y9VWu_V1yCWIgqCbw8CvgQrQrGRjS3xjuHJqqyBNFU1YR6fRpD_ueIIaqtDemUg3box6CApc3rppITVByhhnwIhP3dMsDUlKjaqGOiakpUMVAp0UR78aeRO9LvCBPg1Qmgg9FDT9oZG-5xtWCCC3Z_EUxn31ukyRQ6g52lyVPn7f82-VfADNbZNPMHHjBs_EguRapAhcRRN9P3Tc8HZXq8BQf-C6TD1hA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1074769575</pqid></control><display><type>article</type><title>Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Formenti, Silvia C., M.D ; Hsu, Howard, M.D ; Fenton-Kerimian, Maria, N.P ; Roses, Daniel, M.D ; Guth, Amber, M.D ; Jozsef, Gabor, Ph.D ; Goldberg, Judith D., Sc.D ; DeWyngaert, J. Keith, Ph.D</creator><creatorcontrib>Formenti, Silvia C., M.D ; Hsu, Howard, M.D ; Fenton-Kerimian, Maria, N.P ; Roses, Daniel, M.D ; Guth, Amber, M.D ; Jozsef, Gabor, Ph.D ; Goldberg, Judith D., Sc.D ; DeWyngaert, J. Keith, Ph.D</creatorcontrib><description>Purpose To report the 5-year results of a prospective trial of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation in the prone position. Methods and Materials Postmenopausal patients with Stage I breast cancer with nonpalpable tumors <2 cm, negative margins and negative nodes, positive hormone receptors, and no extensive intraductal component were eligible. The trial was offered only after eligible patients had refused to undergo standard whole-breast radiotherapy. Patients were simulated and treated on a dedicated table for prone setup. 3D-CRT was delivered at a dose of 30 Gy in five 6-Gy/day fractions over 10 days with port film verification at each treatment. Rates of ipsilateral breast failure, ipsilateral nodal failure, contralateral breast failure, and distant failure were estimated using the cumulative incidence method. Rates of disease-free, overall, and cancer-specific survival were recorded. Results One hundred patients were enrolled in this institutional review board-approved prospective trial, one with bilateral breast cancer. One patient withdrew consent after simulation, and another patient elected to interrupt radiotherapy after receiving two treatments. Ninety-eight patients were evaluable for toxicity, and, in 1 case, both breasts were treated with partial breast irradiation. Median patient age was 68 years (range, 53–88 years); in 55% of patients the tumor size was <1 cm. All patients had hormone receptor-positive cancers: 87% of patients underwent adjuvant antihormone therapy. At a median follow-up of 64 months (range, 2–125 months), there was one local recurrence (1% ipsilateral breast failure) and one contralateral breast cancer (1% contralateral breast failure). There were no deaths due to breast cancer by 5 years. Grade 3 late toxicities occurred in 2 patients (one breast edema, one transient breast pain). Cosmesis was rated good/excellent in 89% of patients with at least 36 months follow-up. Conclusions Five-year efficacy and toxicity of 3D-CRT delivered in prone partial breast irradiation are comparable to other experiences with similar follow-up.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2012.01.039</identifier><identifier>PMID: 22494589</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Accelerated partial breast radiotherapy ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal - therapeutic use ; Biological and medical sciences ; Breast Neoplasms - chemistry ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - therapy ; Chemotherapy, Adjuvant ; Combined Modality Therapy - methods ; DEATH ; Disease-Free Survival ; EDEMA ; Female ; Gynecology. Andrology. Obstetrics ; Hematology, Oncology and Palliative Medicine ; HORMONES ; Humans ; IRRADIATION ; Mammary gland diseases ; MAMMARY GLANDS ; Mastectomy, Segmental ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; NEOPLASMS ; Neoplasms, Second Primary ; PAIN ; Patient Positioning - methods ; PATIENTS ; Postmenopause ; Prone Position ; Prone setup ; Prospective Studies ; RADIATION DOSES ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Radiotherapy, Conformal - methods ; SIMULATION ; SURGERY ; TOXICITY ; Tumor Burden ; Tumors ; VERIFICATION</subject><ispartof>International journal of radiation oncology, biology, physics, 2012-11, Vol.84 (3), p.606-611</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-c401cc3b261c91e4747bf7e39521e1bee62031d2013a9a49c7407d8c01cbab733</citedby><cites>FETCH-LOGICAL-c576t-c401cc3b261c91e4747bf7e39521e1bee62031d2013a9a49c7407d8c01cbab733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2012.01.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26404340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22494589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22149555$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Formenti, Silvia C., M.D</creatorcontrib><creatorcontrib>Hsu, Howard, M.D</creatorcontrib><creatorcontrib>Fenton-Kerimian, Maria, N.P</creatorcontrib><creatorcontrib>Roses, Daniel, M.D</creatorcontrib><creatorcontrib>Guth, Amber, M.D</creatorcontrib><creatorcontrib>Jozsef, Gabor, Ph.D</creatorcontrib><creatorcontrib>Goldberg, Judith D., Sc.D</creatorcontrib><creatorcontrib>DeWyngaert, J. Keith, Ph.D</creatorcontrib><title>Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To report the 5-year results of a prospective trial of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation in the prone position. Methods and Materials Postmenopausal patients with Stage I breast cancer with nonpalpable tumors <2 cm, negative margins and negative nodes, positive hormone receptors, and no extensive intraductal component were eligible. The trial was offered only after eligible patients had refused to undergo standard whole-breast radiotherapy. Patients were simulated and treated on a dedicated table for prone setup. 3D-CRT was delivered at a dose of 30 Gy in five 6-Gy/day fractions over 10 days with port film verification at each treatment. Rates of ipsilateral breast failure, ipsilateral nodal failure, contralateral breast failure, and distant failure were estimated using the cumulative incidence method. Rates of disease-free, overall, and cancer-specific survival were recorded. Results One hundred patients were enrolled in this institutional review board-approved prospective trial, one with bilateral breast cancer. One patient withdrew consent after simulation, and another patient elected to interrupt radiotherapy after receiving two treatments. Ninety-eight patients were evaluable for toxicity, and, in 1 case, both breasts were treated with partial breast irradiation. Median patient age was 68 years (range, 53–88 years); in 55% of patients the tumor size was <1 cm. All patients had hormone receptor-positive cancers: 87% of patients underwent adjuvant antihormone therapy. At a median follow-up of 64 months (range, 2–125 months), there was one local recurrence (1% ipsilateral breast failure) and one contralateral breast cancer (1% contralateral breast failure). There were no deaths due to breast cancer by 5 years. Grade 3 late toxicities occurred in 2 patients (one breast edema, one transient breast pain). Cosmesis was rated good/excellent in 89% of patients with at least 36 months follow-up. Conclusions Five-year efficacy and toxicity of 3D-CRT delivered in prone partial breast irradiation are comparable to other experiences with similar follow-up.</description><subject>Accelerated partial breast radiotherapy</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Breast Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Combined Modality Therapy - methods</subject><subject>DEATH</subject><subject>Disease-Free Survival</subject><subject>EDEMA</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>HORMONES</subject><subject>Humans</subject><subject>IRRADIATION</subject><subject>Mammary gland diseases</subject><subject>MAMMARY GLANDS</subject><subject>Mastectomy, Segmental</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>NEOPLASMS</subject><subject>Neoplasms, Second Primary</subject><subject>PAIN</subject><subject>Patient Positioning - methods</subject><subject>PATIENTS</subject><subject>Postmenopause</subject><subject>Prone Position</subject><subject>Prone setup</subject><subject>Prospective Studies</subject><subject>RADIATION DOSES</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Conformal - methods</subject><subject>SIMULATION</subject><subject>SURGERY</subject><subject>TOXICITY</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>VERIFICATION</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsGO0zAQjRCILQt_gFAkhMQlxRM7ccMBqVQsrLQSKxYkbpbjTLouqV3GTqX-PY5adoELpznMe2_mzZssew5sDgzqN5u53ZBvd_OSQTlnMGe8eZDNYCGbglfV94fZjPGaFTyBz7InIWwYYwBSPM7OylI0olo0s8xfk3eYL43BAUlH7PJrTdHqIX9PqEPML4l0Z3W03uXLPiKdGsXKu4C0t26d34y0Rjq8zS_sHosDasq_YBiHGHLf58BYEo0WXQxPs0e9HgI-O9Xz7NvFh6-rT8XV54-Xq-VVYSpZx8IIBsbwtqzBNIBCCtn2EnlTlYDQItYl49Al61w3WjRGCia7hUmsVreS8_Ps3VF3N7Zb7EyaTXpQO7JbTQfltVV_d5y9VWu_V1yCWIgqCbw8CvgQrQrGRjS3xjuHJqqyBNFU1YR6fRpD_ueIIaqtDemUg3box6CApc3rppITVByhhnwIhP3dMsDUlKjaqGOiakpUMVAp0UR78aeRO9LvCBPg1Qmgg9FDT9oZG-5xtWCCC3Z_EUxn31ukyRQ6g52lyVPn7f82-VfADNbZNPMHHjBs_EguRapAhcRRN9P3Tc8HZXq8BQf-C6TD1hA</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Formenti, Silvia C., M.D</creator><creator>Hsu, Howard, M.D</creator><creator>Fenton-Kerimian, Maria, N.P</creator><creator>Roses, Daniel, M.D</creator><creator>Guth, Amber, M.D</creator><creator>Jozsef, Gabor, Ph.D</creator><creator>Goldberg, Judith D., Sc.D</creator><creator>DeWyngaert, J. Keith, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20121101</creationdate><title>Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients</title><author>Formenti, Silvia C., M.D ; Hsu, Howard, M.D ; Fenton-Kerimian, Maria, N.P ; Roses, Daniel, M.D ; Guth, Amber, M.D ; Jozsef, Gabor, Ph.D ; Goldberg, Judith D., Sc.D ; DeWyngaert, J. Keith, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-c401cc3b261c91e4747bf7e39521e1bee62031d2013a9a49c7407d8c01cbab733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Accelerated partial breast radiotherapy</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - chemistry</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Breast Neoplasms - therapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Combined Modality Therapy - methods</topic><topic>DEATH</topic><topic>Disease-Free Survival</topic><topic>EDEMA</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>HORMONES</topic><topic>Humans</topic><topic>IRRADIATION</topic><topic>Mammary gland diseases</topic><topic>MAMMARY GLANDS</topic><topic>Mastectomy, Segmental</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>NEOPLASMS</topic><topic>Neoplasms, Second Primary</topic><topic>PAIN</topic><topic>Patient Positioning - methods</topic><topic>PATIENTS</topic><topic>Postmenopause</topic><topic>Prone Position</topic><topic>Prone setup</topic><topic>Prospective Studies</topic><topic>RADIATION DOSES</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Conformal - methods</topic><topic>SIMULATION</topic><topic>SURGERY</topic><topic>TOXICITY</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>VERIFICATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Formenti, Silvia C., M.D</creatorcontrib><creatorcontrib>Hsu, Howard, M.D</creatorcontrib><creatorcontrib>Fenton-Kerimian, Maria, N.P</creatorcontrib><creatorcontrib>Roses, Daniel, M.D</creatorcontrib><creatorcontrib>Guth, Amber, M.D</creatorcontrib><creatorcontrib>Jozsef, Gabor, Ph.D</creatorcontrib><creatorcontrib>Goldberg, Judith D., Sc.D</creatorcontrib><creatorcontrib>DeWyngaert, J. Keith, Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Formenti, Silvia C., M.D</au><au>Hsu, Howard, M.D</au><au>Fenton-Kerimian, Maria, N.P</au><au>Roses, Daniel, M.D</au><au>Guth, Amber, M.D</au><au>Jozsef, Gabor, Ph.D</au><au>Goldberg, Judith D., Sc.D</au><au>DeWyngaert, J. Keith, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>84</volume><issue>3</issue><spage>606</spage><epage>611</epage><pages>606-611</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose To report the 5-year results of a prospective trial of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation in the prone position. Methods and Materials Postmenopausal patients with Stage I breast cancer with nonpalpable tumors <2 cm, negative margins and negative nodes, positive hormone receptors, and no extensive intraductal component were eligible. The trial was offered only after eligible patients had refused to undergo standard whole-breast radiotherapy. Patients were simulated and treated on a dedicated table for prone setup. 3D-CRT was delivered at a dose of 30 Gy in five 6-Gy/day fractions over 10 days with port film verification at each treatment. Rates of ipsilateral breast failure, ipsilateral nodal failure, contralateral breast failure, and distant failure were estimated using the cumulative incidence method. Rates of disease-free, overall, and cancer-specific survival were recorded. Results One hundred patients were enrolled in this institutional review board-approved prospective trial, one with bilateral breast cancer. One patient withdrew consent after simulation, and another patient elected to interrupt radiotherapy after receiving two treatments. Ninety-eight patients were evaluable for toxicity, and, in 1 case, both breasts were treated with partial breast irradiation. Median patient age was 68 years (range, 53–88 years); in 55% of patients the tumor size was <1 cm. All patients had hormone receptor-positive cancers: 87% of patients underwent adjuvant antihormone therapy. At a median follow-up of 64 months (range, 2–125 months), there was one local recurrence (1% ipsilateral breast failure) and one contralateral breast cancer (1% contralateral breast failure). There were no deaths due to breast cancer by 5 years. Grade 3 late toxicities occurred in 2 patients (one breast edema, one transient breast pain). Cosmesis was rated good/excellent in 89% of patients with at least 36 months follow-up. Conclusions Five-year efficacy and toxicity of 3D-CRT delivered in prone partial breast irradiation are comparable to other experiences with similar follow-up.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22494589</pmid><doi>10.1016/j.ijrobp.2012.01.039</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Accelerated partial breast radiotherapy Aged Aged, 80 and over Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Breast Neoplasms - chemistry Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - therapy Chemotherapy, Adjuvant Combined Modality Therapy - methods DEATH Disease-Free Survival EDEMA Female Gynecology. Andrology. Obstetrics Hematology, Oncology and Palliative Medicine HORMONES Humans IRRADIATION Mammary gland diseases MAMMARY GLANDS Mastectomy, Segmental Medical sciences Middle Aged Neoplasm Recurrence, Local NEOPLASMS Neoplasms, Second Primary PAIN Patient Positioning - methods PATIENTS Postmenopause Prone Position Prone setup Prospective Studies RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy, Conformal - methods SIMULATION SURGERY TOXICITY Tumor Burden Tumors VERIFICATION |
| title | Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients |
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