Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1

We report that loss of HMGN1, a nucleosome-binding protein that alters the compaction of the chromatin fiber, increases the cellular sensitivity to ionizing radiation and the tumor burden of mice. The mortality and tumor burden of ionizing radiation-treated Hmgn1-/- mice is higher than that of their...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-08, Vol.65 (15), p.6711-6718
Hauptverfasser:	BIRGER, Yehudit, CATEZ, Frédéric, FURUSAWA, Takashi, LIM, Jae-Hwan, PRYMAKOWSKA-BOSAK, Marta, WEST, Katherine L, POSTNIKOV, Yuri V, HAINES, Diana C, BUSTIN, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - radiation effects Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - radiation effects Female Fibroblasts - cytology Fibroblasts - radiation effects G2 Phase - radiation effects HMGN1 Protein - deficiency HMGN1 Protein - metabolism HMGN1 Protein - physiology Male Medical sciences Mice Mice, Nude Neoplasms, Radiation-Induced - metabolism Neoplasms, Radiation-Induced - pathology Radiation therapy and radiosensitizing agent Radiation Tolerance - physiology Treatment with physical agents Treatment. General aspects Tumors
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