Chemistry and Structural Biology of DNA Damage and Biological Consequences
The formation of adducts by the reaction of chemicals with DNA is a critical step for the initiation of carcinogenesis. The structural analysis of various DNA adducts reveals that conformational and chemical rearrangements and interconversions are a common theme. Conformational changes are modulated...
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| Veröffentlicht in: | Chemistry & biodiversity 2011-09, Vol.8 (9), p.1571-1615 |
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| container_title | Chemistry & biodiversity |
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| creator | Stone, Michael P. Huang, Hai Brown, Kyle L. Shanmugam, Ganesh |
| description | The formation of adducts by the reaction of chemicals with DNA is a critical step for the initiation of carcinogenesis. The structural analysis of various DNA adducts reveals that conformational and chemical rearrangements and interconversions are a common theme. Conformational changes are modulated both by the nature of adduct and the base sequences neighboring the lesion sites. Equilibria between conformational states may modulate both DNA repair and error‐prone replication past these adducts. Likewise, chemical rearrangements of initially formed DNA adducts are also modulated both by the nature of adducts and the base sequences neighboring the lesion sites. In this review, we focus on DNA damage caused by a number of environmental and endogenous agents, and biological consequences. |
| doi_str_mv | 10.1002/cbdv.201100033 |
| format | Article |
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The structural analysis of various DNA adducts reveals that conformational and chemical rearrangements and interconversions are a common theme. Conformational changes are modulated both by the nature of adduct and the base sequences neighboring the lesion sites. Equilibria between conformational states may modulate both DNA repair and error‐prone replication past these adducts. Likewise, chemical rearrangements of initially formed DNA adducts are also modulated both by the nature of adducts and the base sequences neighboring the lesion sites. 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| fulltext | fulltext |
| identifier | ISSN: 1612-1872 |
| ispartof | Chemistry & biodiversity, 2011-09, Vol.8 (9), p.1571-1615 |
| issn | 1612-1872 1612-1880 1612-1880 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3714022 |
| source | MEDLINE; Wiley Online Library |
| subjects | DNA DNA - chemistry DNA - metabolism DNA Adducts - chemistry DNA Damage DNA Repair DNA Replication Nucleic Acid Conformation Nucleotides |
| title | Chemistry and Structural Biology of DNA Damage and Biological Consequences |
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